Probable Endometrial Carcinoma of the Prostate, Crossed Renal Ectopia and Dermatomyositis in a 32-year-old Man

Abstract

An unusual type of prostatic carcinoma associated with crossed renal ectopia and dermatomyositis is reported in a young man. Infiltration by an epithelial tumor filled the enlarged prostate with soft papillary masses. Cystoprostatectomy and removal of a single large pelvic lymph node metastasis were done. Histologically, the tumor resembled endometrial carcinoma and may have arisen from paramesonephric tissue in the prostate. Large amounts of immunoglobulins were found in the tumor tissue. The patient has survived for more than 5 years, although a slow growing urethral recurrence has been noted.

Identification of autoantibodies elicited in a patient with prostate cancer presenting as dermatomyositis

“…These authors described large numbers of plasma cells within the prostate tissue, and IgG staining within prostate tissue as well as skin biopsies. They could not detect circulating antibodies using techniques available at that time, but suggested that an autoimmune reaction might be involved in the disease process 16 . There has otherwise been no investigation, to our knowledge, prior to our report of an autoimmune association between dermatomyositis and prostate cancer.…”

“…Dermatomyositis has a strong association with malignancy; however, it has most commonly been associated with ovarian cancer and lung cancer 13,27 . To our knowledge, there have only been nine previous case reports of dermatomyositis being associated with prostate cancer 14–22 . Most of these reports describe an initial presentation of dermatomyositis followed by a diagnosis of prostate cancer.…”

“…13,27 To our knowledge, there have only been nine previous case reports of dermatomyositis being associated with prostate cancer. [14][15][16][17][18][19][20][21][22] Most of these reports describe an initial presentation of dermatomyositis followed by a diagnosis of prostate cancer. The first reported case by Rapoport and Omenn in 1968, 15 as well as a similar case by Ansai and Koseki in 1996, 14 describe patients who presented with dermatomyositis, had rapidly progressive and fatal illnesses, and were found on autopsy to have widespread metastatic prostate cancer.…”

“…Dermatomyositis is commonly associated with malignancy, and a recent review suggests that lung cancer and ovarian cancer have the strongest associations with dermatomyositis 13 . At present, to our knowledge there have only been nine case reports in the medical literature of dermatomyositis being associated with prostate cancer 14–22 …”

“…13 At present, to our knowledge there have only been nine case reports in the medical literature of dermatomyositis being associated with prostate cancer. [14][15][16][17][18][19][20][21][22] In the current report, we identified a patient with dermatomyositis whose symptoms were associated with his clinical course of prostate cancer. We hypothesized that autoantibodies to antigens shared by the prostate cancer and muscle tissue might have been elicited in this patient.…”