Probable assignment of the Duffy blood group locus to chromosome 1 in man.

A 60-Year Tale of Spots, Maps, and Genes

“…Early postdoctoral fellows from Britain included David A. Price Evans, who as a postdoc did the classic study of the pharmacogenetics of isoniazid metabolism (17) [at that time the concept and the term pharmacogenetics had scarcely been invented, by Arno Motulsky (93) (13).…”

“…Renwick was involved in several other Moore Clinic linkage studies (2), including assignment of the Duffy blood group locus to chromosome 1 in 1968 (13). A notable contribution by Renwick in the same period was the introduction of the useful term synteny (and syntenic), meaning "on the same chromosome" as opposed to linkage (and linked).…”

A History of Medical Genetics in Pediatrics

“…The introduction of Rhogam led to a precipitous fall in the incidence of kernicterus, a then highly prevalent cause of neonatal brain injury. The blood group systems also proved to be highly effective markers in genetic linkage studies, with the Duffy blood group being the first human autosomal gene to be mapped (37).…”

PCR-generated padlock probes distinguish homologous chromosomes through quantitative fluorescence analysis

“…5 -7 Chromosomal heteromorphisms have been used to distinguish homologous chromosomes, and they were used to map the first gene to a human autosome -the Duffy blood group locus to chromosome 1. 8 The drawback of using morphological differences is that only extreme variants, rare in the human population, can be reliably genotyped, since morphology can change depending on the chromosome preparation and banding technique used. 9,10 A genetic marker should be reproducible and have many resolvable alleles to be maximally informative.…”