1995
DOI: 10.1148/radiology.195.1.7892497
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Probable Alzheimer disease: diagnosis with proton MR spectroscopy.

Abstract: Hydrogen-1 MR spectroscopy enables identification of mild to moderate AD with a specificity and sensitivity that suggest clinical utility.

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Cited by 279 publications
(191 citation statements)
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“…Their advocates assume that due to the lack of detectable metabolites in the CSF (12,13), except for lactate, the effect of CSF contamination is simply to dilute all the concentrations by the same factor.…”
Section: Discussionmentioning
confidence: 99%
“…Their advocates assume that due to the lack of detectable metabolites in the CSF (12,13), except for lactate, the effect of CSF contamination is simply to dilute all the concentrations by the same factor.…”
Section: Discussionmentioning
confidence: 99%
“…Alzheimer disease-A reasonable working hypothesis, subsequently confirmed in myriad studies, suggests that regional reductions in NAA concentration and NAA-creatine ratio are to be found in individual patients and in patient groups who test positive for clinical dementia. Patients with Alzheimer disease consistently show a 15-20% reduction in NAA/Cr (or NAA concentration) in posterior cingulate gyrus gray matter Moats et al, 1994;Shonk et al, 1995;Waldman et al, 2002). The gray matter in the region of the posterior cingulate gyrus has been found to be the most reliable for the diagnosis of this and other dementias, rather than hippocampus, the region selected for PET diagnosis, and postmortem histological examination of Alzheimer disease.…”
Section: Magnetic Resonance Spectroscopy and Imaging Of Naamentioning
confidence: 99%
“…NAA decreases in a variety of neurological disorders including AD. [17][18][19][20][21] The decrease of NAA or the NAA/creatine (Cr) ratio shows a regional variation in AD. [22][23][24] In patients with mild to moderate AD, NAA/Cr levels are lower than normal in the posterior cingulate gyrus, whereas they are normal in the medial occipital lobe, including in the visual cortex.…”
mentioning
confidence: 99%