Probable aerosol transmission of severe fever with thrombocytopenia syndrome virus in southeastern China

Gong, Zhenyu; Gu, Shi-Jian; Zhang, Y.; Sun, Jimin; Wu, Xiaodong; Li, Feng; Shi, Wen; Zhang, P.; Li, D.; Mao, Hongzhen; Zhang, L.; Wen, Dan; Zhou, Bu-Yu; Zhang, Huohuo; Huang, Yu; Zhang, R.; Jiang, Jianmin; Lin, Junfen; Xia, Shichang; Chen, E.; Chen, Z.

doi:10.1016/j.cmi.2015.07.024

Cited by 69 publications

(56 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SFTSV is believed to be transmitted through tick bites, direct contact with SFTS patient secretions or blood, and probable aerosol transmission [14][15][16][17][18]. The SFTSV can be detected in humans, various domestic animals and ticks, and the animals may be a reservoir host in maintaining the life cycle of the SFTSV in nature [9].…”

Section: Introductionmentioning

confidence: 99%

Spatial-temporal characteristics of severe fever with thrombocytopenia syndrome and the relationship with meteorological factors from 2011 to 2018 in Zhejiang Province, China

et al. 2020

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Background Zhejiang Province has the fifth-highest incidence of severe fever with thrombocytopenia syndrome (SFTS) in China. While the top four provinces are all located in northern and central China, only Zhejiang Province is located in the Yangtze River Delta region of southeast China. This study was undertaken to identify the epidemiological characteristics of SFTS in Zhejiang from 2011 to 2018. Methods The epidemic data from SFTS cases in Zhejiang Province from January 2011 to December 2018 were obtained from the China Information Network System of Disease Prevention and Control. Meteorological data were collected from the China Meteorological Data Sharing Service System. A multivariate time series model was used to analyze the heterogeneity of spatial-temporal transmission of the disease. Random forest analysis was performed to detect the importance of meteorological factors and the dose-response association of the incidence of SFTS with these factors. Results In total, 412 SFTS cases (49 fatal) were reported from January 2011 to December 2018 in Zhejiang Province, China. The number of SFTS cases and the number of affected counties increased year by year. The case fatality rate in Zhejiang Province was 11.89%, which was the highest in China. Elderly patients and farmers were the most affected. The total effect values of the autoregressive component, spatiotemporal component and endemic component of the model in all ranges were 0.4580, 0.0377 and 0.0137, respectively. There was obvious heterogeneity across counties for the mean values of the spatiotemporal component and the autoregressive component. The autoregressive component was obviously the PLOS NEGLECTED TROPICAL DISEASES

show abstract

Section: Introductionmentioning

confidence: 99%

Spatial-temporal characteristics of severe fever with thrombocytopenia syndrome and the relationship with meteorological factors from 2011 to 2018 in Zhejiang Province, China

et al. 2020

PLoS Negl Trop Dis

View full text Add to dashboard Cite

show abstract

“…[7][8][9][10] Although SFTSV is believed to be transmitted through direct contact with SFTS patients' secretion or blood, and probable aerosol transmission, most SFTS cases were infected through tick bites. [11][12][13][14][15][16] Severe fever with thrombocytopenia syndrome is a climate-sensitive disease and most cases were reported from April to October. 6 Meteorological factors may influence SFTSV ecology both directly and indirectly by affecting tick growth dynamics, tick-human interactions, and virus replication.…”

Section: Introductionmentioning

confidence: 99%

Association between Severe Fever with Thrombocytopenia Syndrome Incidence and Ambient Temperature

Sun

Lu²,

Yang³

et al. 2018

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Severe fever with thrombocytopenia syndrome (SFTS) is emerging in China. To explore the lagged effects and nonlinear association between temperature and SFTS, we collected data on ambient temperature and SFTS cases and analyzed the data using a distributed lag nonlinear model. A total of 1,933 SFTS cases were reported in the study area from 2011 to 2015. Our study revealed a nonlinear relationship between weekly temperature and SFTS. The exposure-response curve was an approximately reversed U-shaped peak at 23°C. High temperatures had acute and short-term effects, whereas low temperatures had persistent and long-term effects. The effects of lower temperatures (1.62°C and 6.97°C) could last 24 weeks, but the effect of 29.30°C was not significant at lag 8 weeks. Our results provide information to better understand the effect of temperature variation on SFTS and may have policy implications for disease prevention and control.

show abstract

“…SFTSV is believed to be transmitted through tick bites, direct contact with SFTS patients’ blood or secretion, and probable aerosol transmission101112131415. Identification of risk factors is of vital importance for the control and prevention of SFTSV infection.…”

mentioning

confidence: 99%

Factors associated with Severe Fever with Thrombocytopenia Syndrome infection and fatal outcome

Sun

Gong

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Severe fever with thrombocytopenia syndrome (SFTS) is emerging in China and the incidence increased year by year. In this study, we conducted case control study to explore factors associated with SFTS virus (SFTSV) infection and fatal outcome. In the study of factors associated with SFTSV infection, a total of 216 individuals participated the study, including 72 cases and 144 matched controls. There were significant differences in proportion of history of tick bite and breeding domestic animals between cases and controls. Of note, individuals who were unclear whether they had been bitten by ticks had the highest risk of SFTSV infection and odds ratio (OR) was 10.222. In the study of factors associated with SFTS fatal outcome, a total of 129 cases participated the study including 16 deaths and 113 survivors. Significant differences were observed in body mass index (BMI), intervals from illness onset to confirmation, and proportion of gingival hemorrhage between deaths and survivors, whose ORs of these factors were 3.903, 1.996, and 3.826, respectively. Our results suggest that all patients with fever, thrombocytopenia and leukocytopenia in SFTS endemic areas should be suspected of SFTS, even they don’t have history of tick bite, and more intense treatment should be administered to patients with abnormal BMI before laboratory parameters are detected.

show abstract

Probable aerosol transmission of severe fever with thrombocytopenia syndrome virus in southeastern China

Cited by 69 publications

References 15 publications

Spatial-temporal characteristics of severe fever with thrombocytopenia syndrome and the relationship with meteorological factors from 2011 to 2018 in Zhejiang Province, China

Spatial-temporal characteristics of severe fever with thrombocytopenia syndrome and the relationship with meteorological factors from 2011 to 2018 in Zhejiang Province, China

Association between Severe Fever with Thrombocytopenia Syndrome Incidence and Ambient Temperature

Factors associated with Severe Fever with Thrombocytopenia Syndrome infection and fatal outcome

Contact Info

Product

Resources

About