Probability to tolerate laryngoscopy and noxious stimulation response index as general indicators of the anaesthetic potency of sevoflurane, propofol, and remifentanil

Abstract

The triple interaction model estimates the potency of any combination of sevoflurane, propofol, and remifentanil expressed as either PTOL or NSRI.

The effect of remifentanil used during caesarean section on maternal hemodynamics and neonatal outcome - comparison of two dosing regimens

“…Synergism between remifentanil and anesthetics has been described in numerous studies [17,18,19]. Our results are in agreement with those data.…”

Adaptation of non-linear mixed amount with zero amount response surface model for analysis of concentration-dependent synergism and safety with midazolam, alfentanil, and propofol sedation

“…The new C 50r , g 0 , and g were linearly interpolated from the original parameters in a single study. 26 This was different from our approach where n and log 10 U 50 were cubic polynomial functions. Interactions between midazolam, alfentanil, and propofol have also been performed using logit and probit curves.…”

Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration

“…23 110 111 For propofol and remifentanil, Nieuwenhuijs and colleagues 108 described a supra-additive interaction on cardiorespiratory control. More recently, a triple drug interaction (propofol, sevoflurane, and remifentanil) model was described by Hannivoort and colleagues 35 for tolerance of laryngoscopy and its derivate, the newly developed noxious stimulation response index. In this triple drug interaction study, they described all drug combinations with regard to the probability of tolerance to laryngoscopy (PTOL).…”

“…A synergistic effect was found for remifentanil when combined with propofol and sevoflurane. 35 As a result of its ultra-short-acting pharmacokinetics and its PD profile, remifentanil is suitable for use for sedation, and this indication is becoming more frequently the responsibility of anaesthetists. Several studies have been performed to provide insight into the effects of propofol-remifentanil drug combinations on end points relevant to sedation, such as prevention of the gag reflex on oesophageal instrumentation.…”

“…propofol and sevoflurane). Used with permission fromHannivoort and colleagues, previously published as a web supplement 35. Description of additivity, supra-additivity, and infra-additivity.…”