Probability Learning in T-maze and Skinner Box in the Rat

Hiraoka, Kyoichi

doi:10.2502/janip1944.23.69

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Pigeons maximize reinforcement under such circumstances (Herrnstein and Loveland, 1975;Hartl and Fantino, 1996). Rats are sometimes sub-optimal (Hiraoka, 1974) but can achieve optimality under some circumstances (Hiraoka, 1977) and generally outperform probability matching and humans (Wine®eld, 1980). Cats and monkeys maximize (Warren, 1980), and so do armadillos (Mustaca, Papini and Aanni, 1985).…”

Section: Discussionmentioning

confidence: 96%

What does and does not alleviate base-rate neglect under direct experience

Goodie

Fantino

1999

J. Behav. Decis. Making

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Section: Discussionmentioning

confidence: 96%

What does and does not alleviate base-rate neglect under direct experience

Goodie

Fantino

1999

J. Behav. Decis. Making

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“…The synthetic peptide-based strategy for photoactivation of protein function may expand the versatility of protein caging approaches since the photolabile protecting group can be easily introduced into the peptide by means of standard solid-phase methods in a site-specific manner. [5][6][7][8][9] For example, Hiraoka and Hamachi succeeded in the photoactivation of semisynthetic ribonuclease S by the reconstitution of S-protein and S-peptide modified with a 2-nitrobenzyl moiety. 8 Reconstitution of split-GFP has been utilized for analysis of protein-protein interactions [9][10][11] and direct detection of specific DNA 12,13 or RNA sequences by ternary complexation.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8][9] For example, Hiraoka and Hamachi succeeded in the photoactivation of semisynthetic ribonuclease S by the reconstitution of S-protein and S-peptide modified with a 2-nitrobenzyl moiety. 8 Reconstitution of split-GFP has been utilized for analysis of protein-protein interactions [9][10][11] and direct detection of specific DNA 12,13 or RNA sequences by ternary complexation. 14,15 To our knowledge, however, control of split-GFP reconstitution by incorporation of a synthetic photocleavable element has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Design and semisynthesis of photoactivable split‐GFP by incorporation of photocleavable functionality

et al. 2013

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The design of proteins whose structure and function can be manipulated by the external stimuli has been of great interest in the field of protein engineering. In particular, caged proteins which can be activated by photo-irradiation become powerful tools for investigating a variety of biological events. Although protein caging is straightforward to render light-responsive protein functions, this approach mostly have difficulties based on the preparation of caged proteins in which amino acid residues required for biological activities must be specifically modified with synthetic photolabile groups. The synthetic peptide-based strategy for photoactivation of protein function may expand the versatility of protein caging approaches since the photolabile protecting group can be easily introduced into the peptide by means of standard solid-phase methods in a site-specific manner. In this study, we designed a new photoactivable green fluorescent protein (GFP), in which a relatively short C-terminal fragment (residues 214-230) of a dissected protein was modified with 7-diethylamino-4-hydroxymethylcoumarin (DECM) as a photoresponsive-protecting group. The introduced DECM unit completely inhibited the reconstitution with the GFP N-terminal fragment (residues 2-214). However, irradiation of visible light (>400 nm) resulted in efficient cleavage of DECM group, leading to acceleration of protein reassembly and concomitant GFP fluorescence recovery. These results demonstrated direct control of protein structure and function by application of the synthetic photocleavable functionality to a fragmented protein. The combined system of fragmented proteins and synthetic photocleavable elements will provide the useful and potentially wide applicable strategy for the regulation of protein structure and function by the light in a temporal and spacial manner.

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Probability Learning in T-maze and Skinner Box in the Rat

Cited by 2 publications

References 11 publications

What does and does not alleviate base-rate neglect under direct experience

What does and does not alleviate base-rate neglect under direct experience

Design and semisynthesis of photoactivable split‐GFP by incorporation of photocleavable functionality

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