Proazulenes from Achillea asplenifolia

Kastner, Ulrike; Jurenitsch, J.; Glasl, Sabine; Baumann, Andreas; Robien, Wolfgang; Kubelka, W.

doi:10.1016/0031-9422(92)80478-w

Cited by 18 publications

(8 citation statements)

References 3 publications

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“…The authors declared that this compound has not been previously reported in plants. Besides, 8 -angeloxy-artabsin, 2,3-dihidro-dezacetoxi-matricin were determined as most frequent and important azulenogenic compounds not only in A. collina but in the related A. roseo-alba and A. asplenifolia, too [31,32]. According to further references, the last species contains a wide spectrum of guaianolides including 8-deacetyl-4-epi-matricin, rupicolin A and B [33].…”

Section: Guaianolidesmentioning

confidence: 99%

Biological Activities of Yarrow Species (Achillea spp.)

Németh

Bernáth

2008

CPD

134

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The genus Achillea consists of about 140 perennial herbs native to the Northern hemisphere. Traditional indications of their use include digestive problems, liver and gall-bladder conditions, menstrual irregularities, cramps, fever, wound healing. The Commission E approves its internal use for loss of appetite and dyspeptic ailments (gastric catarrh, spastic discomfort), externally it is used in form of sitz bath or as a compress against skin inflammation, slow healing wounds, bacterial or fungal infections. In the last decades, pharmacological studies became intensive, although human clinical investigations are still rare. Recent findings have confirmed several traditional uses. The largest number of data accumulated for antioxidant and anti-inflammatory effects. There are positive results on the analgesic, anti-ulcer, choleretic, hepatoprotective and wound healing activities. First results on other interesting therapeutical areas - antihypertensive, antidiabetic, antitumor, antispermatogenic activities -need confirmation. Yarrow can be used also as an insect repellent. Contact dermatitis as adverse effect may be connected to sesquiterpenes. The diversity and complexity of the effective compounds of yarrow species explains the broad spectrum of their activity. According to the literature the pharmacological effects are mainly due to the essential oil, proazulenes and other sesquiterpene lactones, dicaffeoylquinic acids and flavonoids. Synergistic actions of these and other compounds are also supposed. Achillea species have different chemical and therapeutical values. Despite of numerous data, correct evaluation of the results is difficult because of missing generally accepted taxonomical nomenclature. The used chemical-analytical methods and bio-assays are utmost diverse, making the comparison complicated. Further research on the activity is needed using exactly defined plant material, standardized methods and chemical analysis.

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Section: Guaianolidesmentioning

confidence: 99%

Biological Activities of Yarrow Species (Achillea spp.)

Németh

Bernáth

2008

CPD

134

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“…8-Desacetyl-4-epi-matricin (1) was isolated from Achillea asplenifolia (Kastner et al, 1992). The EI spectrum showed the molecular ion (2) was isolated from A. roseoalba .…”

Section: Resultsmentioning

confidence: 99%

Electron Impact- and Chemical Ionization‐Mass Spectrometry of Naturally Occurring Sesquiterpene Lactones from Achillea spp.

Reznicek¹,

Kastner²,

Glasl³

1997

Phytochem. Anal.

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“…Studies of plant secondary metabolites can provide additional characteristics for taxonomic differentiation. Some authors [1,2] have reported that relative ontogenetic stability of sesquiterpenoids or essential oil composition in A. millefolium group could be a taxonomically useful tool for classification within the species. Several phytochemical studies previously focused mainly on azulenes and proazulenes (sesquiterpenic lactones) as the most characteristic compounds in yarrow plants [1,[3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Some authors [1,2] have reported that relative ontogenetic stability of sesquiterpenoids or essential oil composition in A. millefolium group could be a taxonomically useful tool for classification within the species. Several phytochemical studies previously focused mainly on azulenes and proazulenes (sesquiterpenic lactones) as the most characteristic compounds in yarrow plants [1,[3][4][5][6][7][8][9]. However, chamazulene was found within the three principal constituents only in a small part of investigated A. millefolium essential oils [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Essential oil composition of two yarrow taxonomic forms

Judžentienė¹,

Mockutė²

2010

Open Life Sciences

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Differences in essential oil composition of wild Achillea millefolium L., collected at five habitats in Lithuania, where plants with pink (f. rosea) and white (f. millefolium) flowers grow together, were reported. For the first time, oils of different plant organs (inflorescences and leaves) of both forms from every population were analysed in detail. Chemical analysis was performed by GC and GC-MS. The most predominant constituents of the oils were nerolidol (9.4-31.9%, in 11 out of 20 samples), caryophyllene oxide (8.4-23.0%, 4 leaf oils), ß-pinene (8.0-15.2%, 2 samples), eudesmol (11.8-15.8%, 2 leaf oils) and 1,8-cineole (11.9%, one inflorescence oil). Domination of nerolidol was mostly characteristic of A. millefolium f. rosea essential oils (in 8 out of 10 oils). The inflorescences biosynthesised markedly larger amounts of nerolidol and ß-pinene than those of the leaves. An opposite correlation was observed for caryophyllene oxide and eudesmol. Chamazulene (≤2.7%) was determined only in six oils. The 65 identified constituents made up 75.4-96.5% of the oils.© Versita Sp. z o.o.

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Proazulenes from Achillea asplenifolia

Cited by 18 publications

References 3 publications

Biological Activities of Yarrow Species (Achillea spp.)

Biological Activities of Yarrow Species (Achillea spp.)

Electron Impact- and Chemical Ionization‐Mass Spectrometry of Naturally Occurring Sesquiterpene Lactones from Achillea spp.

Essential oil composition of two yarrow taxonomic forms

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