Proapoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder

Hussain, Syed A.; Ganesan, Raji; Hiller, Louise; Murray, Paul G.; El-Magraby, M. M.; Young, Lawrence S.

doi:10.1038/sj.bjc.6600765

Cited by 40 publications

(26 citation statements)

References 43 publications

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“…Transgenic CD40L expression in murine tumor cells enhances antitumor immunity (43,44). This is relevant to clinical data showing that CD40L expression is significantly associated with improved prognosis in bladder cancer patients (35). Our data show that CD40-CD40L is associated not only with down-regulatory effects of B cells on NK cells and T cells but also with the potential for stimulating antitumor immunity, such as IFN-g production.…”

Section: Discussionsupporting

confidence: 62%

“…Enhanced tumor immunity in BKO mice is correlated with IFN-g production from NK and CD8 T cells, which is partially dependent on CD40L expression on tumor cells. CD40L is expressed in several human cancer cells with both hematopoietic and nonhematopoietic origins, such as T-cell lymphoma (31), renal carcinoma (32), melanoma (33), breast cancer (34), and bladder cancer (35), although the effects of B cells on CD40L-expressing tumors remain unclear. Our data support a model whereby B-cell stimulation via CD40 results in IL-10 secretion (36), which in turn diminishes CD8 and NK cell IFN-g secretion, antitumor activity, and CD8 T-cell memory development.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibitory Effects of B Cells on Antitumor Immunity

Inoue

Leitner²,

Golding³

et al. 2006

Cancer Research

296

217

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show abstract

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of B Cells on Antitumor Immunity

Inoue

Leitner²,

Golding³

et al. 2006

Cancer Research

296

217

View full text Add to dashboard Cite

show abstract

“…[8][9][10][11][12][13][14][15][16][17][18] However, none of these studies accounted for the influence of smoking on protein alterations or outcomes in their cohorts. Furthermore, these studies did not profile such a comprehensive biomarker panel involving multiple cellular processes on a single cohort.…”

Section: Discussionmentioning

confidence: 99%

“…Proteins central to key cellular processes commonly implicated in urothelial tumorigenesis such as apoptosis, cell-cycle regulation, inflammation, angiogenesis, and invasion were immunohistochemically profiled; 7 several of these biomarkers have been previously identified as being individually prognostic in UCB, although none were combined in a broad multi-pathway panel. [8][9][10][11][12][13][14][15][16][17][18] This was an effort to identify a marker panel that could predict outcome independent of standard criteria and smoking history.…”

Section: Introductionmentioning

confidence: 99%

560 Combination of Molecular Alterations and Smoking Intensity Predicts Bladder Cancer Outcome: A Report From the Los Angeles Cancer Surveillance Program

Mitra¹,

Castelao²,

Hawes³

et al. 2012

Journal of Urology

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Background-Traditional single-marker and multimarker molecular profiling approaches in bladder cancer do not account for major risk factors and their influence on clinical outcome. This study examined the prognostic value of molecular alterations across all disease stages after accounting for clinicopathological factors and smoking, the most common risk factor for bladder cancer in the developed world, in a population-based cohort.

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“…Su valor como factor predictivo en el cáncer vesical está todavía también por determinar. Los estudios recientes mayoritariamente consideran que la expresión inmunohistoquímica de esta proteína no presenta un valor significativo ni en el análisis univariante ni en el multivariante 1, [30][31][32][33][34] . En tumores pT1G3, Wolf HK y cols.…”

Section: Inmunohistoquímica De Bcl-2unclassified

Valor pronóstico de progresión de las moléculas reguladoras del ciclo celular en tumores vesicales T1G3

et al. 2005

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RESUMEN VALOR PRONÓSTICO DE PROGRESIÓN DE LAS MOLÉCULAS REGULADORAS DEL CICLOCELULAR EN TUMORES VESICALES T1G3 Introducción y Objetivos: El tumor vesical T1G3 constituye el grupo de tumores superficiales más agresivo. Nuevos factores pronósticos en el campo de la citogenética y la biología molecular han sido analizados, con resultados a menudo contradictorios, siendo escasos los trabajos específicos en tumores T1G3. Nuestro objetivo es determinar si en este grupo de tumores los marcadores inmunohistoquímicos presentan valor predictivo de progresión clínicamente útil, y por tanto con validez para indicar una actitud terapéutica precoz más idónea.Material y Métodos: Estudio retrospectivo de una serie de 83 pacientes afectos de tumor vesical T1G3, sobre los que analizamos un total de 14 variables; entre los nuevos factores predictivos: la determinación inmunohistoquímica de las proteínas reguladoras del ciclo celular: p53, p21 y bcl-2, así como la proteína Ki-67 como marcador de proliferación celular. Mediante análisis de regresión logística establecemos las variables pronósticas independientes para progresión tumoral.Resultados: El punto de corte establecido para Ki67 y p53 fue el 40% de células inmunomarcadas, 20% para p21 y 10% para Bcl-2. El análisis univariante puso de manifiesto diferentes tasas de progresión y tiempos libres de progresión en función de la inmunotinción de Ki67 y p53; sin embargo, la regresión logística demostró que solo la inmunohistoquímica de p53 presentaba valor predictivo independiente.Conclusiones: La determinación inmunohistoquímica de p53 presenta valor predictivo de progresión clínicamente útil en tumores vesicales T1G3, de manera que su determinación puede constituir un factor fundamental en las estrategias de tratamiento de estos tumores.Palabras clave: T1G3. Inmunohistoquímica. p53. ABSTRACT PROGNOSTIC VALUE FOR PROGRESSION OF THE REGULATING PROTEINS OF THE CELLULAR CYCLE IN PT1G3BLADDER TUMOURS Introduction and objective: Bladder tumor T1G3 constitutes the group of superficial tumors more aggressive. New prognostic factors in the field of the cytogenetics and molecular biology have been analyzed, with often contradictory results, being little the specific works in tumors T1G3. Our objective is to determine if in this group of tumors the immunohistochemical markers present predictive value of clinically useful progression, and therefore with validity to indicate more suitable a precocious therapeutic attitude Material and methods: Retrospective study of a series of 83 patients affected of bladder tumor T1G3, on which we analyzed a total of 14 variables; between the new predictive factors: the immunohistochemical determination of regulating proteins of the cellular cycle: p53, p21 and bcl-2, as well as the Ki-67 protein like marker of cellular proliferation. By means of logistic regression analisys we establish the independent prognostic variables for tumorlike progression.Results: The cut point established for Ki67 and p53 was 40% of inmmunomarked cells, 20% for p21 and 10% for Bc...

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Proapoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder

Cited by 40 publications

References 43 publications

Inhibitory Effects of B Cells on Antitumor Immunity

Inhibitory Effects of B Cells on Antitumor Immunity

560 Combination of Molecular Alterations and Smoking Intensity Predicts Bladder Cancer Outcome: A Report From the Los Angeles Cancer Surveillance Program

Valor pronóstico de progresión de las moléculas reguladoras del ciclo celular en tumores vesicales T1G3

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