Proanthocyanidins in grape seeds and their role in gut microbiota-white adipose tissue axis

Ferreira, Yasmin Alaby Martins; Jamar, Giovana; Estadella, Débora; Pisani, Luciana Pellegrini

doi:10.1016/j.foodchem.2022.134405

Cited by 15 publications

(8 citation statements)

References 68 publications

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“…[ 1 ] WAT and BAT are key metabolic tissues that show molecular adaptations to photoperiod, involving changes on their morphology and gene expression. [ 3 ] In this context, (poly)phenol consumption can help organisms adapt to the upcoming environmental conditions, [ 26 ] also affecting the adipose tissue, [ 27 ] which can be beneficial for their global metabolism. In our study, we focused on the effects of GSPE supplementation under different photoperiod conditions on the expression of different metabolic and endocrine markers of WAT (considering subcutaneous and visceral depots) and BAT.…”

Section: Discussionmentioning

confidence: 99%

Photoperiod‐Dependent Effects of Grape‐Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats

Navarro‐Masip

Manocchio

Rodríguez

et al. 2023

Molecular Nutrition Food Res

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ScopeVariations in photoperiod patterns drive metabolic adaptations in mammals, involving important changes in body weight and adiposity. Moreover, (poly)phenols can help heterotrophs adopt metabolic adaptations to face the upcoming environmental conditions. Particularly, proanthocyanidins from grape‐seeds show photoperiod‐dependent effects on different metabolic parameters. The present study aims to explore whether grape‐seed proanthocyanidin extract (GSPE) consumption differently affects the expression of metabolic markers in WAT (subcutaneous and visceral depots) and BAT in a photoperiod‐dependent manner.Methods and resultsGSPE (25 mg kg−1 day−1) is orally administrated for 4 weeks to healthy rats exposed to three photoperiods (L6, L12, and L18). In WAT, GSPE consumption significantly upregulates the expression of lipolytic genes in all photoperiods, being accompanied by increased serum concentrations of glycerol and corticosterone only under the L6 photoperiod. Moreover, adiponectin mRNA levels are significantly upregulated in response to GSPE regardless of the photoperiod, whereas Tnfα and Il6 expression are only downregulated in L6 and L18 photoperiods but not in L12. In BAT, GSPE upregulates Pgc1α expression in all groups, whereas the expression of Pparα is only increased in L18.ConclusionsThe results indicate that GSPE modulates the expression of important metabolic markers of WAT and BAT in a photoperiod‐dependent manner.

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Section: Discussionmentioning

confidence: 99%

Photoperiod‐Dependent Effects of Grape‐Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats

Navarro‐Masip

Manocchio

Rodríguez

et al. 2023

Molecular Nutrition Food Res

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“…Cyclooxygenase (COX) is a key enzyme that promotes cancer progression through arachidonic acid metabolism. 26 The anti-inflammatory mechanism of CS and its components involves the activation of the mitogen-activated protein kinase (MAPK) signal pathway, inflammatory related enzymes, and the regulation of nuclear factor kappa B (NF-κB) pathways. 21 Among them, MAPK signaling pathway is closely related to the occurrence of various cancers, and drugs targeting the key targets of this pathway for cancer therapy have been marketed in recent years.…”

Section: Anti-cancer Activitymentioning

confidence: 99%

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

Chen,

Wu,

Zhu

et al. 2024

Food Funct.

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“…In the last decade, many researchers have opened the way to evaluate the role of PAs on health. Most studies evaluated PAs’ extracts from apple, blueberry, cocoa, carob, and grape seeds (a major source of PAs) [ 29 , 58 ]. The consumption of various sources of PAs has a wide variety of beneficial effects in maintaining or improving intestinal function.…”

Section: Gut Microbiota Modulation By Dietary Proanthocyanidins In Me...mentioning

confidence: 99%

Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome

Redondo-Castillejo

Garcimartín

Hernández-Martín

et al. 2023

IJMS

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The metabolic syndrome (MS) is a cluster of risk factors, such as central obesity, hyperglycemia, dyslipidemia, and arterial hypertension, which increase the probability of causing premature mortality. The consumption of high-fat diets (HFD) is a major driver of the rising incidence of MS. In fact, the altered interplay between HFD, microbiome, and the intestinal barrier is being considered as a possible origin of MS. Consumption of proanthocyanidins (PAs) has a beneficial effect against the metabolic disturbances in MS. However, there are no conclusive results in the literature about the efficacy of PAs in improving MS. This review allows a comprehensive validation of the diverse effects of the PAs on the intestinal dysfunction in HFD-induced MS, differentiating between preventive and therapeutic actions. Special emphasis is placed on the impact of PAs on the gut microbiota, providing a system to facilitate comparison between the studies. PAs can modulate the microbiome toward a healthy profile and strength barrier integrity. Nevertheless, to date, published clinical trials to verify preclinical findings are scarce. Finally, the preventive consumption of PAs in MS-associated dysbiosis and intestinal dysfunction induced by HFD seems more successful than the treatment strategy.

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Proanthocyanidins in grape seeds and their role in gut microbiota-white adipose tissue axis

Cited by 15 publications

References 68 publications

Photoperiod‐Dependent Effects of Grape‐Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats

Photoperiod‐Dependent Effects of Grape‐Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome

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