Proanthocyanidine in EGb 761® reduzieren oxidativen Stress in vitro und verbessern in vivo die durch Scopolamin induzierte kognitive Beeinträchtigung

Ginkgo biloba leaf extract EGb 761® as a paragon of the product by process concept

“…Although the model used by Bader et al (2018) replicates many features of the whole brain, it cannot supersede in vivo experiments. Comparing two finished products in a mouse model of spontaneous alternations in the T-maze, the EGb 761 ® containing product more efficiently protected against scopolamine-induced cognitive impairment than another product containing G. biloba extract with a lower PAC content ( Sens-Albert et al, 2021a ; Sens-Albert et al, 2021b ). Those observations verify the assumption that EGb 761 ® and other extracts are dissimilar in their effects both in vitro and in vivo .…”

“…However, other work described here was done using the higher oligomeric PACs, which are present in concentrations more likely to contribute to the overall pharmacologic effects of the extract. For instance, Ginkgo PACs were found to be potent radical scavengers in vitro in cell-free systems ( Qa’dan et al, 2011 ; Cao et al, 2018a ; Ellnain-Wojtaszek et al, 2003 ), in an assay using retinal pigment epithelial cells ( Li et al, 2021 ), or in a neuronal cell line ( Sens-Albert et al, 2021a ). Interestingly, medication containing EGb 761 ® had a more potent anti-oxidative effect than medication containing G. biloba extract with a much lower PAC content.…”