Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway

Wu, Xiaodong; Yu, Haiyang; Zhou, Haichao; Li, Zihua; Huang, Hui; Xiao, Fajiao; Xu, Shaochen; Yang, Yunfeng

doi:10.1111/jcmm.15818

Cited by 15 publications

(7 citation statements)

References 54 publications

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“…OPCs show their antineoplastic capacity in cells through a variety of pathways. For example, proanthocyanidins B2 can reduce the expression of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt); in this typical cancer pathway, proanthocyanidins B2 inds directly to specific points on protein kinase B (Akt) to reduce its expression, but does not have antitumor activity after mutations at specific points [126][127][128]. It was also found that proanthocyanidins B2 can also increase caspase-3 or caspase-9 in gastric cancer cells, thereby increasing tumor cell apoptosis, reducing the expression of related proteins through the Akt/mammalian target of rapamycin (Akt/mTOR) pathway [129].…”

Section: Antineoplastic and Prevention Of Cancer Metastasismentioning

confidence: 99%

Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials

et al. 2023

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Oligomeric Proanthocyanidins (OPCs), as a class of compounds widely found in plants, are particularly abundant in grapes and blueberries. It is a polymer comprising many different monomers, such as catechins and epicatechins. The monomers are usually linked to each other by two types of links, A-linkages (C-O-C) and B-linkages (C-C), to form the polymers. Numerous studies have shown that compared to high polymeric procyanidins, OPCs exhibit antioxidant properties due to the presence of multiple hydroxyl groups. This review describes the molecular structure and natural source of OPCs, their general synthesis pathway in plants, their antioxidant capacity, and potential applications, especially the anti-inflammatory, anti-aging, cardiovascular disease prevention, and antineoplastic functions. Currently, OPCs have attracted much attention, being non-toxic and natural antioxidants of plant origin that scavenge free radicals from the human body. This review would provide some references for further research on the biological functions of OPCs and their application in various fields.

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Section: Antineoplastic and Prevention Of Cancer Metastasismentioning

confidence: 99%

Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials

et al. 2023

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“…EGFR-facilitated tumor progression and gemcitabine resistance in OS were mediated through the PI3K/AKT pathway [60]. Moreover, proanthocyanidin B2 (PB2) inhibited the proliferation and induced the apoptosis of OS cells by suppressing the PI3K/AKT signaling pathway [61], whereas aclidinium bromide inhibited OS cell growth by regulating the PI3K/AKT signaling pathway [62]. As is evident, the PI3K/Akt signaling pathway significantly contributes to the development, progression, and therapeutic responsiveness of OS.…”

Section: Pik3/akt/mtor Pathwaymentioning

confidence: 99%

Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis

Nirala

Yamamichi

Yustein

2023

IJMS

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Osteosarcoma (OS) is the predominant primary bone tumor in the pediatric and adolescent populations. It has high metastatic potential, with the lungs being the most common site of metastasis. In contrast to many other sarcomas, OS lacks conserved translocations or genetic mutations; instead, it has heterogeneous abnormalities, including somatic DNA copy number alteration, ploidy, chromosomal amplification, and chromosomal loss and gain. Unfortunately, clinical outcomes have not significantly improved in over 30 years. Currently, no effective molecularly targeted therapies are available for this disease. Several genomic studies showed inactivation in the tumor suppressor genes, including p53, RB, and ATRX, and hyperactivation of the tumor promoter genes, including MYC and MDM2, in OS. Alterations in the major signaling pathways, including the PI3K/AKT/mTOR, JAK/STAT, Wnt/β-catenin, NOTCH, Hedgehog/Gli, TGF-β, RTKs, RANK/RANKL, and NF-κB signaling pathways, have been identified in OS development and metastasis. Although OS treatment is currently based on surgical excision and systematic multiagent therapies, several potential targeted therapies are in development. This review focuses on the major signaling pathways of OS, and we propose a biological rationale to consider novel and targeted therapies in the future.

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“…In recent years, anti-cancer properties of natural compounds have become a research hotspot. In a study by Wu et al [ 34 ] , proanthocyanidin B2 was shown to inhibit the proliferation and induce apoptosis of OS cells by downregulating the PI3K/AKT/NF-κB signaling pathway. Zhang et al [ 35 ] discovered that alantolactone (ALT) inhibits the growth of OS cells by downregulating the PI3K/AKT signaling pathway, suggesting that ALT is a potential candidate for the treatment of OS.…”

Section: The Regulatory Role Of Signaling Pathways In Osmentioning

confidence: 99%

Research progress in the mechanism and treatment of osteosarcoma

Bian,

Liu,

Zhao

et al. 2023

Chinese Medical Journal

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Osteosarcoma (OS) is the most common primary malignant bone tumor that more commonly occurs in children and adolescents. The most commonly used treatment for OS is surgery combined with chemotherapy, but the treatment outcomes are typically unsatisfactory. High rates of metastasis and post-treatment recurrence rates are major challenges in the treatment of OS. This underlines the need for studying the in-depth characterization of the pathogenetic mechanisms of OS and development of more effective therapeutic modalities. Previous studies have demonstrated the important role of the bone microenvironment and the regulation of signaling pathways in the occurrence and development of OS. In this review, we discussed the available evidence pertaining to the mechanisms of OS development and identified therapeutic targets for OS. We also summarized the available treatment modalities for OS and identified future priorities for therapeutics research.

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Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway

Cited by 15 publications

References 54 publications

Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials

Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials

Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis

Research progress in the mechanism and treatment of osteosarcoma

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