Proanthocyanidin and fish oil potent activity against cisplatin-induced renal cell cycle arrest and apoptosis in rats

Hassan, Hanaa A.; Edrees, G.M.; El-Gamel, Ezz M.; El-Sayed, El-Sayed M.

doi:10.3109/0886022x.2015.1073528

Cited by 10 publications

(6 citation statements)

References 46 publications

(49 reference statements)

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“…Caspases are mediators in the process of cell apoptosis. 66 They are proenzymes that control a cascade of proteolytic events ending in cell death. 67 Caspase-3 is particularly involved in the process of apoptosis by controlling Ca/Mg-dependent endonuclease which is involved in segmenting DNA ending in chromatin condensation and DNA fragmentation.…”

Section: Discussionmentioning

confidence: 99%

Dietary zinc modifies diabetic-induced renal pathology in rats

Elsaed

Mohamed

2016

Renal Failure

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This study was conducted to investigate how far dietary zinc (Zn) modifies the histomorphological alterations induced by diabetes in rat kidneys. The animals were divided into negative control group (10 rats). Diabetes was induced in thirty animals by streptozotocin. After confirming diabetes, the animals were divided into three groups (n = 10). Group II served as the positive control group (fed on standard diet), group III was fed on Zn deficient diet, and group IV was fed on Zn supplemented diet. Caspase-3 immune staining was used to estimate the caspase activity. Stereological procedures were used to measure the quantity of the immune stain and the surface area of the Bowman’s space. The renal cortices of group II rats revealed apparent widening of Bowman’s spaces with few apoptotic figures. The filtration barrier showed thickening of the basement membrane. The proximal convoluted tubules showed patchy loss of the apical microvilli with swollen mitochondria. The distal convoluted tubules revealed area of irregular basal enfolding. The picture was aggravated by Zn deficiency in group III besides areas of cortical interstitial fibrosis. The histopathological alterations were minimal in the cortices of group IV. A significant increase of the Bowman’s space surface area in group II and IV while decrease in group III compared with group I. The expression of Caspase-3 density was significantly increased in group II and III compared with group I while in group IV was non significant. In conclusion, dietary Zn modulated renal cortical changes caused by diabetes in rats.

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Section: Discussionmentioning

confidence: 99%

Dietary zinc modifies diabetic-induced renal pathology in rats

Elsaed

Mohamed

2016

Renal Failure

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“…That study showed that grape seed proanthocyanidins could prevent oxidative stress, genomic integrity, and cell death ( 49 ). The proanthocyanidins found in grape seed can prevent cisplatin-induced cytotoxic side effects in the kidney through modifying expression of the proteins associated with apoptosis and antioxidant property ( 50 ). Gao et al investigated the protective effects of grape seed proanthocyanidin extract on nephrotoxicity in male laboratory mice, and found that cotreatment with proanthocyanidins and cisplatin could result in decreased BUN level, renal index, and serum creatinine.…”

Section: Resultsmentioning

confidence: 99%

“…Lycopene: Carotenoids including lycopene are among the most potent antioxidants and prevent other oxidants from inducing toxic effects in the body. Hassan et al ( 50 ) reported that lycopene prevented cisplatin nephrotoxicity in mice through a complex process. Indeed, lycopene exerts its effects through reducing serum creatinine and BUN, preventing increase in MDA and isoprostane, decreasing renal bax protein as well as renal HSP60 and HSP70, increasing Bcl-2 expression, and decreasing lipids peroxidation ( 68 ).…”

Section: Resultsmentioning

confidence: 99%

Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review

Heidari-Soreshjani¹,

Asadi-Samani²,

Yang³

et al. 2017

J Nephropathol

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Context: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, attention has recently been paid to seeking out alternatives such as nature-based drugs that are effective but less toxic. In this regard, this systematic review article is to report and introduce the most important medicinal plants and their derivatives that are used to reduce anticancer drug-induced nephrotoxicity. Evidence Acquisitions: The word nephrotoxicity alongside the words cancer or chemotherapy in combination with some herbal terms such as medicinal plant, plants, herbs, and extracts were administered to search for relevant publications indexed in PubMed. Results: According to this study, 16 medicinal plants, 12 plant-based derivatives, and three traditional plant-based formulations were found to help control and modulate anticancer drug-induced nephrotoxicity indices. Conclusions: Anticancer drugs cause nephrotoxicity through activating pathways of oxidative stress, damage-associated molecular patterns (DAMPs) production, inflammatory processes, and cell apoptosis, while medicinal plants and their derivatives can cause reduction in nephrotoxicity and anticancer drugs side effects via their antioxidant and anti-inflammatory properties.

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“…Flax and fish oil also showed normal kidney histology. Similarly, dietary flax and fish oil have shown to improve renal abnormalities in rats (Hassan et al 2015 ; Velasquez et al 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative anti-inflammatory and lipid-normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats

et al. 2016

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BackgroundEmerging evidence suggests beneficial effects of omega-3 fatty acids on diabetic complications. The present study compared the progressive effects of metformin and flax/fish oil on lipid metabolism, inflammatory markers, and liver and renal function test markers in streptozotocin-nicotinamide-induced diabetic rats.MethodsStreptozotocin-induced diabetic rats were randomized into control and four diabetic groups: streptozotocin (STZ), metformin (200 mg/kg body weight (b.w)/day (D)), flax and fish oil (500 mg/kg b.w/D).ResultsMetformin and flax and fish oil exhibited increased expression of transcription factor peroxisome proliferator-activated receptor γ while the treatment downregulated sterol regulatory element-binding protein 1 and nuclear factor kβ as compared to those of the STZ group. Apart from modulation of transcription factor expression, the expression of fatty acid synthase, long chain acyl CoA synthase, and malonyl-CoA-acyl carrier protein transacylase was lowered by flax/fish oil treatment. Serum cholesterol, triglycerides, and VLDL were also significantly reduced in the treatment groups as compared to those in the STZ group. Although pathological abnormalities were seen in the liver and kidneys of rats on metformin, no significant changes in liver/renal function markers were observed at day 15 and day 30 of the treatment groups. Flax/fish oil had protective effects toward pathological abnormalities in the liver and kidney. Flax/fish oil improved lipid profile and alkaline phosphatase at day 30 as compared to that at day 15.ConclusionsThe present study demonstrates potential beneficial effects of metformin and flax/fish oil intervention in improving serum lipid profile by regulating the expression of transcription factors and genes involved in lipid metabolism in diabetic rats. In addition, these interventions also lowered the expression of atherogenic cytokines. The protective effects of flax/fish oil are worth investigating in human subjects on metformin monotherapy.

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Proanthocyanidin and fish oil potent activity against cisplatin-induced renal cell cycle arrest and apoptosis in rats

Cited by 10 publications

References 46 publications

Dietary zinc modifies diabetic-induced renal pathology in rats

Dietary zinc modifies diabetic-induced renal pathology in rats

Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review

Comparative anti-inflammatory and lipid-normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats

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