Proactive infliximab is more effective than vedolizumab in inducing fecal calprotectin remission in inflammatory bowel disease

Rodrigues, I; Serrazina, Juliana; Botto, I; Bernardo, Sónia; Gonçalves, Ana; Valente, A; Santos, Paula Moura; Correia, Luís; Marinho, Rui Tato

doi:10.1080/00365521.2022.2076567

Cited by 1 publication

(8 citation statements)

References 19 publications

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“…In terms of conference proceedings, 43,474 abstracts were initially screened and a final screen led to four conference abstracts. One of these abstracts had been published in full and utilised in preference to the abstract 27 . The PRISMA flow diagram below (Figure 1) outlines the study screening search process 28 …”

Section: Resultsmentioning

confidence: 99%

“…Nine were RCTs 17,19,20,[29][30][31][32][33][34] and the remaining were cohort studies. There were four prospective cohort studies, [35][36][37][38] 11 retrospective cohort studies [6][7][8]18,27,[39][40][41][42][43][44] and two that were both prospective and retrospective cohort studies. 5,45 Table 1 shows a summary of the studies.…”

Section: Re Sultsmentioning

confidence: 99%

“…One of these abstracts had been published in full and utilised in preference to the abstract. 27 The PRISMA flow diagram below (Figure 1) outlines the study screening search process. 28 There were 26 studies in total.…”

Section: Re Sultsmentioning

confidence: 99%

“…There were six studies included in the need for surgical intervention, all using IFX. 5,8,27,37,40,45 There were 580 patients included in the proactive TDM arm and 787 patients in the SOC arm. There was no significant risk reduction in the need for surgery in the TDM arm (RR 0.51, 95% CI 0.25-1.02, p=0.06, Figure 5).…”

Section: Effect Of Therapeutic Drug Monitoring On Surgical Interventionmentioning

confidence: 99%

“…Eight studies explored proactive TDM for clinical remission or respo nse. 17,19,20,27,29,31,33,34 There were 704 in the proactive TDM arm and 632 in the SOC arm. There was no significant difference between the two arms in terms of clinical remission or response (RR 1.07, 95% CI 0.97-1.18, p = 0.19, Figure 2).…”

Section: Effects Of Proactive Therapeutic Drug Monitoring On Clinical...mentioning

confidence: 99%

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Meta‐analysis: The efficacy of therapeutic drug monitoring of anti‐TNF‐therapy in inflammatory bowel disease

Sethi

Dias

Kumar

et al. 2022

Aliment Pharmacol Ther

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Background and Aims: This systematic review and meta-analysis aimed to determine whether the use of therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD) patients on anti-tumour necrosis factor (anti-TNF) therapy results in improved rates of clinical and endoscopic remission, surgery, corticosteroid-free remission and hospitalisation. Methods: MEDLINE, EMBASE, EMBASE classic, PubMed, Cochrane central databases register of controlled trials and Cochrane Specialised Trials Register were searched between 01 Janurary 1946 and 08 April 2022. Randomised controlled trials (RCTs) and prospective and retrospective observational studies were included, comparing TDM to standard of care (SOC) or reactive vs proactive TDM. Results were reported as pooled relative risks (RR) with 95% confidence intervals (95% CI).Results: Twenty-six studies, including 9 RCTs, were included. Compared to SOC, proactive TDM was associated with a significantly decreased risk of treatment failure (RR 0.64, 95% CI 0.48-0.85 p<0.01), and a non-significant decrease in need for surgery (RR 0.51, 95% CI 0.25-1.02) and hospitalisation (RR 0.64, 95% CI 0.40-1.00).Furthermore compared to SOC, Proactive TDM was associated with higher rates of endoscopic remission (RR 1.19,) and clinical remission (RR 1.07, 95% CI 0.97-1.18). Compared to reactive TDM, proactive TDM was associated with significant decreased risk of treatment failure (RR 0.46, 95% CI 0.21 = 0.98, p = 0.04) and significant reduction in hospitalisation (RR 0.33, 95% CI 0.21-0.54, p < 0.01).Conclusions: Compared to SOC, proactive TDM was associated with significant benefit in reducing treatment failure. Compared to reactive TDM, proactive TDM led to a significant reduction in hospitalisation and treatment failure. More studies with larger RCTs and standardised assays are needed to substantiate these results and validate the cost-effectiveness of TDM.

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Section: Resultsmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

Section: Effect Of Therapeutic Drug Monitoring On Surgical Interventionmentioning

confidence: 99%

Section: Effects Of Proactive Therapeutic Drug Monitoring On Clinical...mentioning

confidence: 99%

See 3 more Smart Citations

Meta‐analysis: The efficacy of therapeutic drug monitoring of anti‐TNF‐therapy in inflammatory bowel disease

Sethi

Dias

Kumar

et al. 2022

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

Proactive infliximab is more effective than vedolizumab in inducing fecal calprotectin remission in inflammatory bowel disease

Cited by 1 publication

References 19 publications

Meta‐analysis: The efficacy of therapeutic drug monitoring of anti‐TNF‐therapy in inflammatory bowel disease

Meta‐analysis: The efficacy of therapeutic drug monitoring of anti‐TNF‐therapy in inflammatory bowel disease

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