Pro38 Costs of Treatments of Pulmonary Hypertension in Poor Population of Colombia.

Abstract

Objectives: PPP is a chronic, debilitating, painful inflammatory skin disease characterized by localized, sterile pustules on the palms of the hands and soles of the feet. By understanding the burden of disease in this population, targeted interventions that improve patient quality of life can be developed. To our knowledge, this study is the first of its kind to describe HCRU in patients with PPP. Methods: Patients were identified as having PPP if they had $1 inpatient or 2 outpatient ICD-10 L40.3 diagnosis codes, separated by 30 to 365 days. All analyses were conducted via the Aetion Evidence Platform TM v3.17, using Optum® Clinformatics TM Data Mart, a US administrative claims database. The study period was from October 1, 2015 to March 31, 2019, with the first diagnosis code marking the index date. A general population matched cohort (MC) of 4:1, based on age and sex, was generated for context. No formal comparisons were conducted. Patient characteristics, treatment, and all-cause HCRU calculated for each visit type (inpatient, outpatient, and emergency department [ED]) during the 12-month follow up (FU) were analyzed. Results: 1291 patients with PPP were identified at baseline, and 708 had $12 months' FU. Compared with the MC, patients with PPP were more likely to have a diagnosis of hyperlipidemia (PPP: 28.7% vs MC: 20.0%), anxiety (PPP: 7.6% vs MC: 5.5%), and depression (PPP: 7.0% vs MC: 5.1%) at baseline. During the 12-month FU, 391 patients with PPP (55.2%) were treated with a systemic therapy (biologic or non-biologic) and had a median of 18.5 outpatient visits, 23.6% of patients had ED visits (median: 1.0), and 10% had inpatient visits (median: 1.0). Conclusions: Patients with PPP have more comorbidities than those in the MC, as well as high HCRU, highlighting an unmet need among these patients.