Pro-tumoral functions of tumor-associated macrophage EV-miRNA

Cocks, Alexander; Vecchio, Filippo Del; Martinez-Rodriguez, Verena; Schukking, Monique; Fabbri, Muller

doi:10.1016/j.semcancer.2021.08.001

Cited by 18 publications

(11 citation statements)

References 66 publications

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“…Macrophages play an important role in a wide variety of physiologic and pathologic processes ( Cocks et al, 2021 ). Previous studies have found that osteogenic and angiogenic effects may be indirectly regulated through the immune response, in which macrophage polarization and cytokine secretion highly affect the fate of bone implants ( Chen et al, 2020 ; Wang Y. et al, 2021 ; Li et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensionally Printed Ti2448 With Low Stiffness Enhanced Angiogenesis and Osteogenesis by Regulating Macrophage Polarization via Piezo1/YAP Signaling Axis

Tang

Wei

Tian

et al. 2021

Front. Cell Dev. Biol.

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Previous studies have found that the novel low-elastic-modulus Ti2448 alloy can significantly reduce stress shielding and contribute to better bone repair than the conventional Ti6Al4V alloy. In this study, the promotion of osteogenesis and angiogenesis by three-dimensionally printed Ti2448 were also observed in vivo. However, these were not significant in a series of in vitro tests. The stiffness of materials has been reported to greatly affect the response of macrophages, and the immunological regulation mediated by macrophages directly determines the fate of bone implants. Therefore, we designed more experiments to explore the role of three-dimensionally printed Ti2448 in macrophage activation and related osteogenesis and angiogenesis. As expected, we found a significant increase in the number of M2 macrophages around Ti2448 implants, as well as better osteogenesis and angiogenesis in vivo. In vitro studies also showed that macrophages pre-treated with Ti2448 alloy significantly promoted angiogenesis and osteogenic differentiation through increased PDGF-BB and BMP-2 secretion, and the polarization of M2 macrophages was enhanced. We deduced that Ti2448 promotes angiogenesis and osteogenesis through Piezo1/YAP signaling axis-mediated macrophage polarization and related cytokine secretion. This research might provide insight into the biological properties of Ti2448 and provide a powerful theoretical supplement for the future application of three-dimensionally printed Ti2448 implants in orthopaedic surgery.

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Section: Introductionmentioning

confidence: 99%

Three-Dimensionally Printed Ti2448 With Low Stiffness Enhanced Angiogenesis and Osteogenesis by Regulating Macrophage Polarization via Piezo1/YAP Signaling Axis

Tang

Wei

Tian

et al. 2021

Front. Cell Dev. Biol.

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“…The M2 phenotype is essential for immune responses mediated by helper T cells 2 involving humoral immunity, wound healing and tissue remodeling 63 . Besides, the M2 phenotype produces growth factors that activate tissue repair and angiogenesis, has high clearance activity, and suppresses the adaptive immune response 64 . The M2 phenotype can be subdivided into three subgroups, M2a, M2b, and M2c, with M2a macrophages triggered by IL‐4 or IL‐13 and M2b macrophages triggered by the immune complex toll‐like receptor (TLR) and M2c macrophages.…”

Section: Characteristics Of the Components Of The Glioma Immune Micro...mentioning

confidence: 99%

Advances in research on immune escape mechanism of glioma

Guo

Wang

2023

CNS Neurosci Ther

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Background Glioma is the most common primary intracranial malignancy in clinical practice, and in particular, IDH‐wildtype glioblastoma has the worst prognosis. In recent years, surgical resection combined with simultaneous radiotherapy and immune checkpoint inhibitors has made some progress, but the efficacy is still not satisfactory, which may be related to the low immunogenicity of glioma cells and the tumor immunosuppressive microenvironment. Methods A comprehensive review of relevant literature was conducted to explore the mechanisms by which tumors suppress antitumor immune responses and produce escape, with a focus on the immune cells in the tumor microenvironment (TME). Results The mechanisms involved in immune evasion of glioma cells are complex and involve with immune cell differentiation and function. Conclusion Our review emphasizes the need for a more profound comprehension of the mechanisms involved in immune response and immune evasion in glioma, to formulate more efficacious treatment modalities.

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“…They are usually divided into three categories based on their size and origin: exosomes (30-150 nm), microvesicles (MVs, 50 nm-1 µm), and apoptotic bodies (50 nm-5 µm) (157). EVs can be efficiently internalized by other cells, mediating the exchange of biological substances between cells and playing important roles in tumor progression (158)(159)(160). The potential application of macrophage-derived exosomes and MVs in cancer therapy has attracted great attention recently because of their excellent biocompatibility and high NP-loading capacities (161,162).…”

Section: Macrophage Membrane-coated Nps (Mmc-nps) and Macrophage Extracellular Vesicle-coated Nps (Mevc-nps)mentioning

confidence: 99%

Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy

et al. 2022

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Macrophages play critical roles in tumor progression. In the tumor microenvironment, macrophages display highly diverse phenotypes and may perform antitumorigenic or protumorigenic functions in a context-dependent manner. Recent studies have shown that macrophages can be engineered to transport drug nanoparticles (NPs) to tumor sites in a targeted manner, thereby exerting significant anticancer effects. In addition, macrophages engineered to express chimeric antigen receptors (CARs) were shown to actively migrate to tumor sites and eliminate tumor cells through phagocytosis. Importantly, after reaching tumor sites, these engineered macrophages can significantly change the otherwise immune-suppressive tumor microenvironment and thereby enhance T cell-mediated anticancer immune responses. In this review, we first introduce the multifaceted activities of macrophages and the principles of nanotechnology in cancer therapy and then elaborate on macrophage engineering via nanotechnology or genetic approaches and discuss the effects, mechanisms, and limitations of such engineered macrophages, with a focus on using live macrophages as carriers to actively deliver NP drugs to tumor sites. Several new directions in macrophage engineering are reviewed, such as transporting NP drugs through macrophage cell membranes or extracellular vesicles, reprogramming tumor-associated macrophages (TAMs) by nanotechnology, and engineering macrophages with CARs. Finally, we discuss the possibility of combining engineered macrophages and other treatments to improve outcomes in cancer therapy.

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Pro-tumoral functions of tumor-associated macrophage EV-miRNA

Cited by 18 publications

References 66 publications

Three-Dimensionally Printed Ti2448 With Low Stiffness Enhanced Angiogenesis and Osteogenesis by Regulating Macrophage Polarization via Piezo1/YAP Signaling Axis

Three-Dimensionally Printed Ti2448 With Low Stiffness Enhanced Angiogenesis and Osteogenesis by Regulating Macrophage Polarization via Piezo1/YAP Signaling Axis

Advances in research on immune escape mechanism of glioma

Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy

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