“…In fact, the effects observed after FPR2 activation include the activation of phospholipase A2 (PLA2), phospholipase C (PLC) isoforms, protein kinase C (PKC), phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), mitogen-activated protein kinase (MAPK) pathway as well as p38MAPK, which modulate proliferation, differentiation, apoptosis, cellular communication and other intracellular functions. Furthermore, phosphorylation of cytosolic tyrosine kinases, phosphorylation and nuclear translocation of regulatory transcription factors, calcium release and oxidant production so far were demonstrated [ 49 ]. Among the post-translational modifications of FPR2, phosphorylation processes, which are determined by a balance between protein kinases and protein phosphatases, seem to be of great importance [ 1 ].…”