“…Snail is a labile protein with an estimated half-life of about 30 min (Park et al, 2010;. Several studies demonstrated that Snail can be quickly degraded via ubiquitinationmediated protein hydrolysis pathway (Suresh et al, 2016;Gudey et al, 2017). Several ring domain-containing E3 ligases, such as Fbxl5 (Wu et al, 2015), Fbxl14 (Vinas-Castells et al, 2010;Diaz and de Herreros, 2016), Fbxw1 (b-Trcp) (Vinas-Castells et al, 2014;Diaz and de Herreros, 2016), Fbxo11 (Zheng et al, 2014;Jin et al, 2015), and SCF-FbxO45 (Xu et al, 2015), have been identified to ubiquitinate Snail and promote its degradation in various cell types.…”