Pro-inflammatory potential of wood smoke and traffic-derived particles in a monocytic cell line

Kocbach, Anette; Namork, Ellen; Schwarze, Per E.

doi:10.1016/j.tox.2008.02.014

Cited by 83 publications

(68 citation statements)

References 74 publications

(100 reference statements)

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“…(Cheng et al, 2004) DEPs are rather heterogeneous in their composition but share a consensus structure with a carbonaceous core, whereon a multitude of hydrocarbon compounds (10-20,000) can be attached onto, (Riedl & Diaz-Sanchez, 2005;Costa & Dreher, 1997) with the latter encompassing about 20-40% (mass per mass) of DEPs. (Lubitz et al, 2009) Within this attached layer, PAHs (Chang, 2010;Nel, 1998;Takenaka et al, 1995) , nitro-PAHs, (Kocbach, 2008) but also bioavailable (transition) metals, such as Fe, Cu, Ni, V, Zn, nitrates, sulfates, (Chang, 2010;Costa & Dreher, 1997) allergens, (Ormstad et al, 1995;Riedl & Diaz-Sanchez, 2005) plant debris, (Solomon, 2002); Taylor et al, 2002) mineral constituents, endotoxins, e.g. lipopolysaccharide (LPS), hopanes, and steranes have been identified.…”

Section: Composition Of Diesel-and Ultrafine Nano-particlesmentioning

confidence: 99%

“…lipopolysaccharide (LPS), hopanes, and steranes have been identified. (Kocbach et al, 2008) In the case of wood smoke particles (WSPs), the PAH content is 150-fold higher (9750 ng/mg) in comparison to DEPs. WEPs slso contained sugars, methoxy-phenols, PAHs, benzene and alkali salts.…”

Section: Composition Of Diesel-and Ultrafine Nano-particlesmentioning

confidence: 99%

“…For WSPs, the spectrum of core-attached compounds is also influenced by the combustion temperature. (Kocbach et al, 2008) In case of organic dust, as produced by modern www.intechopen.com farming operations, the nano-aerosol fraction is composed of particulate matter and microbial compounds, including endotoxins, such as LPS, and peptidoglycans (PGNs). The latter compound class represents cell wall constituents particularly of gram-positive bacteria.…”

Section: Composition Of Diesel-and Ultrafine Nano-particlesmentioning

confidence: 99%

“…(Chan et al, 2008: Alessandrini et al, 2009 Particle interaction with epithelial cells and macrophages are known to trigger inflammatory signalling pathways. (Kocbach et al, 2008) Figure 6 reveals the cyto-toxicological potential of nano-particles by emphasizing oxidative stress induced by these xenobiotic substances. (Oberdörster et al, 2007) Due to their oxidative properties (step "a" in Figure 6), nano-particles are capable to induce lipid peroxidation.…”

Section: Toxicity At the Cellular Levelmentioning

confidence: 99%

“…Evidently, carbon particles with adhered organic compounds are endocytosed and PAHs get activated by intracellular ROS. (Kocbach et al, 2008) The increase in transcription induced by PAHs has been postulated to be promoted by a cytoplasmatic aryl hydrocarbon receptor (AhR), acting as a nuclear transporter/DNA binding protein PAH complex. Once released from DEPs, PAHs enter adjacent cells due to their hydrophobicity and adhere to the PAH ligand binding part of AhR which is then translocated to the nucleus.…”

Section: Toxicity At the Cellular Levelmentioning

confidence: 99%

See 4 more Smart Citations

Exposure to Nano-Sized Particles and the Emergence of Contemporary Diseases with a Focus on Epigenetics

Madl¹

2012

Air Pollution - Monitoring, Modelling and Health

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Section: Composition Of Diesel-and Ultrafine Nano-particlesmentioning

confidence: 99%

Section: Composition Of Diesel-and Ultrafine Nano-particlesmentioning

confidence: 99%

Section: Composition Of Diesel-and Ultrafine Nano-particlesmentioning

confidence: 99%

Section: Toxicity At the Cellular Levelmentioning

confidence: 99%

Section: Toxicity At the Cellular Levelmentioning

confidence: 99%

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Exposure to Nano-Sized Particles and the Emergence of Contemporary Diseases with a Focus on Epigenetics

Madl¹

2012

Air Pollution - Monitoring, Modelling and Health

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Biomarkers of oxidative stress and inflammation after wood smoke exposure in a reconstructed Viking Age house

Jensen

Karottki

Christensen

et al. 2014

Environ and Mol Mutagen

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Exposure to particles from combustion of wood is associated with respiratory symptoms, whereas there is limited knowledge about systemic effects. We investigated effects on systemic inflammation, oxidative stress and DNA damage in humans who lived in a reconstructed Viking Age house, with indoor combustion of wood for heating and cooking. The subjects were exposed to high indoor concentrations of PM2.5 (700-3,600 µg/m(3)), CO (10.7-15.3 ppm) and NO2 (140-154 µg/m(3)) during a 1-week stay. Nevertheless, there were unaltered levels of genotoxicity, determined as DNA strand breaks and formamidopyrimidine DNA glycosylase and oxoguanine DNA glycosylase 1 sensitive sites in peripheral blood mononuclear cells. There were also unaltered expression levels of OGG1, HMOX1, CCL2, IL8, and TNF levels in leukocytes. In serum, there were unaltered levels of C-reactive protein, IL6, IL8, TNF, lactate dehydrogenase, cholesterol, triglycerides, and high-density lipoproteins. The wood smoke exposure was associated with decreased serum levels of sICAM-1, and a tendency to decreased sVCAM-1 levels. There was a minor increase in the levels of circulating monocytes expressing CD31, whereas there were unaltered expression levels of CD11b, CD49d, and CD62L on monocytes after the stay in the house. In conclusion, even a high inhalation exposure to wood smoke was associated with limited systemic effects on markers of oxidative stress, DNA damage, inflammation, and monocyte activation.

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Toxicology of Ambient Particulate Matter

Berlo

Hullmann

Schins

2012

Experientia Supplementum

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It is becoming increasingly clear that inhalation exposure to particulate matter (PM) can lead to or exacerbate various diseases, which are not limited to the lung but extend to the cardiovascular system and possibly other organs and tissues. Epidemiological studies have provided strong evidence for associations with chronic obstructive pulmonary disease (COPD), asthma, bronchitis and cardiovascular disease, while the evidence for a link with lung cancer is less strong. Novel research has provided first hints that exposure to PM might lead to diabetes and central nervous system (CNS) pathology. In the current review, an overview is presented of the toxicological basis for adverse health effects that have been linked to PM inhalation. Oxidative stress and inflammation are discussed as central processes driving adverse effects; in addition, profibrotic and allergic processes are implicated in PM-related diseases. Effects of PM on key cell types considered as regulators of inflammatory, fibrotic and allergic mechanisms are described.

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Pro-inflammatory potential of wood smoke and traffic-derived particles in a monocytic cell line

Cited by 83 publications

References 74 publications

Exposure to Nano-Sized Particles and the Emergence of Contemporary Diseases with a Focus on Epigenetics

Exposure to Nano-Sized Particles and the Emergence of Contemporary Diseases with a Focus on Epigenetics

Biomarkers of oxidative stress and inflammation after wood smoke exposure in a reconstructed Viking Age house

Toxicology of Ambient Particulate Matter

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