Pro-inflammatory genotype as a risk factor for aPL-associated thrombosis: Report of a family with multiple anti-phospholipid positive members

Angelis, Valentina De; Scurati, Silvia; Raschi, Elena; Liutkus, Aurélia; Belot, Alexandre; Borghi, Maria Orietta; Meroni, Pier Luigi; Cimaz, Rolando

doi:10.1016/j.jaut.2008.11.002

Cited by 27 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti-phospholipid-mediated EC perturbation may represent the first hit responsible for the thrombophilic diathesis in APS, a condition that would favour clotting in the presence of an additional second hit as inflammatory mediators [5,27]. On the other hand, EC dysfunction may also be responsible for an accelerated atherosclerosis as shown in other systemic autoimmune diseases [28].…”

Section: Discussionmentioning

confidence: 99%

Patients with antiphospholipid syndrome display endothelial perturbation

Cugno

Borghi

Lonati

et al. 2010

Journal of Autoimmunity

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Patients with antiphospholipid syndrome display endothelial perturbation

Cugno

Borghi

Lonati

et al. 2010

Journal of Autoimmunity

View full text Add to dashboard Cite

“…More than one‐fourth of biomass‐using women of this study were positive for aCL of the IgG isotype against only 2% positive cases among LPG users. Rise in aCL titer among biomass‐using women is important because it increases the risk of spontaneous abortion (Goel et al., 2006) and thrombosis (De Angelis et al., 2009). Elevated level of anticardiolipin IgG has been found in association with stroke and highly elevated titer (>20 GPL) with first‐ever ischemic stroke (Lien et al., 2006).…”

Section: Discussionmentioning

confidence: 99%

Hypertension with elevated levels of oxidized low-density lipoprotein and anticardiolipin antibody in the circulation of premenopausal Indian women chronically exposed to biomass smoke during cooking

et al. 2010

View full text Add to dashboard Cite

The study showing high risk of developing cardiovascular diseases (CVD) among poor, underprivileged women in their reproductive ages in rural India is important from public health perspectives. It may motivate the government and the regulatory agencies of the country to take a serious note of the indoor air pollution (IAP) from biomass fuel use as it threatens the health of millions of women, children, and the elderly who mostly stay indoor. We hope the findings will strengthen the demand for setting up a standard for indoor air quality in the country in the line of national ambient air quality standard. The findings may also inspire the authorities to take measures for the reduction in IAP by improving housing, kitchen ventilation, and cook stoves. Moreover, the parameters used in this study can be utilized for large, population-based studies to identify women at a higher risk of developing CVD so that medical intervention can be taken at the formative stage of a disease.

show abstract

“…Targeting signalling molecules may be helpful, but are likely to cause unwanted side effects given the importance of TLR4 in the immune system. On the other hand, it has confirmed the link between TLR4 SNPs and aPL-mediated thrombosis De Angelis et al, 2009). In APS, where long-term suppression of procoagulant effects of aPL is essential, TLR4 SNPs may open new effective avenues to classify patients according to their different risk categories to progress to the vascular manifestations of the syndrome (Raschi et al, 2008).…”

Section: Potential Immunomodulatory Approaches In Apsmentioning

confidence: 89%

The role of TLR4 in pathophysiology of antiphospholipid syndrome‐associated thrombosis and pregnancy morbidity

et al. 2013

View full text Add to dashboard Cite

SummaryThe antiphospholipid syndrome (APS) is an autoimmune disease characterized by the clinical features of recurrent thrombosis in the venous or arterial circulation and fetal losses. Antiphospholipid antibodies (aPL), particularly against the phospholipid binding protein beta-2 glycoprotein I (b2GPI), play an important role in APS pathological mechanisms. aPL can activate intracellular signal transduction in a b2GPI-dependent manner to induce inflammatory responses, and promote hypercoagulable state and recurrent spontaneous abortion when b2GPI is associated with the cell surface receptor. In vivo and in vitro studies show that Annexin A2 (ANXA2) is the high affinity receptor that connects b2GPI to the target cells. However, ANXA2 is not a transmembrane protein and lacks an intracellular signal transduction pathway. Growing evidences suggest that the transmembrane protein toll-like receptor 4 (TLR4) might act as an 'adaptor' for intracellular signal transduction. This review focuses on the role of TLR4 and its signalling pathway in APS pathological mechanisms which will help us better understand the pathological processes of this syndrome.

show abstract

Pro-inflammatory genotype as a risk factor for aPL-associated thrombosis: Report of a family with multiple anti-phospholipid positive members

Cited by 27 publications

References 22 publications

Patients with antiphospholipid syndrome display endothelial perturbation

Patients with antiphospholipid syndrome display endothelial perturbation

Hypertension with elevated levels of oxidized low-density lipoprotein and anticardiolipin antibody in the circulation of premenopausal Indian women chronically exposed to biomass smoke during cooking

The role of TLR4 in pathophysiology of antiphospholipid syndrome‐associated thrombosis and pregnancy morbidity

Contact Info

Product

Resources

About