Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium
Dora Angyal,
Tessa A. Groeneweg,
Anny Leung
et al.
Abstract:Background
Loss of CFTR-dependent anion and fluid secretion in the ducts of the exocrine pancreas is thought to contribute to the development of pancreatitis, but little is known about the impact of inflammation on ductal CFTR function. Here we used adult stem cell-derived cell cultures (organoids) obtained from porcine pancreas to evaluate the effects of pro-inflammatory cytokines on CFTR function.
Methods
Organoids were cultured from porcine panc… Show more
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