Pro-guest and acyclic cucurbit[n]uril conjugated polymers for the controlled release of anti-tumor drugs

Abstract

We report "pro-guest" and acyclic cucurbit[n]uril conjugated polymers as supramolecular drug delivery systems (DDSs). These supramolecular DDSs could encapsulate anti-tumor drugs. Under acidic conditions, an acid-labile "pro-guest" degraded to become a "competing guest", which displaced and released the encapsulated drug at a tunable rate.

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

“…Controlled drug release was not detected at pH 7.4. The drug‐loaded citraconic amide polymer displayed efficient internalization by HeLa cells at pH 6.0, attributed to the fast degradation [43] . Supramolecular assemblies combining CB[7], CB[8], and proteins have been explored for cancer photodynamic therapy by using various photosensitizers (acridine orange, methylene blue or cationic porphyrin).…”

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A New Fluorescent Sensor for Fe3+ Based on Glycoluril Molecular Clip

“…And this supramolecular assembly is used for bioimaging in vitro with good biocompatibility . By modifying acyclic cucurbit[n]uril conjugated polymers with pro‐guest, pH‐responsive controlled release was achieved with a tunable rate based on ‘‘pro‐guest’’‐to‐guest conversion and cargo displacement …”