Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation

Jantová, Soňa; Mrvová, Nataša; Hudec, Roman; Sedlák, J; Panik, Miroslav; Milata, Viktor

doi:10.1016/j.tiv.2016.02.012

Cited by 6 publications

(6 citation statements)

References 59 publications

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“…How is enoxacin activated by UVA irradiation? Previously, the phototoxicity of another new quinolone was thought to be due to ROS generation by UV exposure; however, the details underlying this remain unknown (13). Therefore, we investigated the effects of histidine and NaN3 as scavengers of singlet oxygen, mannitol as a scavenger of hydroxy radical, and SOD as a scavenger of superoxide anion on apoptosis induced by enoxacin with UVA irradiation (11,12).…”

Section: Discussionmentioning

confidence: 99%

Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation

Nishi

Kato

Sakurai

et al. 2017

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Pancreatic cancer is one of the deadliest human cancers. In the current study, we investigated the possibility of a new treatment strategy using a combination of the new fluoroquinolone, enoxacin, and mild ultraviolet A (UVA) irradiation. Enoxacin with UVA irradiation increased the number of annexin V-positive (apoptotic) pancreatic cancer cells in time- and concentration-dependent manners, whereas alone neither had these effects. In addition, enoxacin with UVA irradiation induced cleavage of poly (ADP-ribose) polymerase in AsPC1 human pancreatic cancer cells. Moreover, the singlet oxygen scavengers, histidine and sodium azide, and the hydroxyl radical scavenger, mannitol, significantly suppressed apoptosis induced by enoxacin and UVA irradiation, respectively. These results suggest that UVA irradiation activates enoxacin, after which activated enoxacin induces apoptosis of AsPC1 cells through generation of reactive oxygen species. Therefore, the combination of enoxacin with mild UVA irradiation may be a useful method for treating pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation

Nishi

Kato

Sakurai

et al. 2017

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“…Cytotoxic tests showed that derivative E2 h evoked significant cytotoxic activity towards leukemia cell lines (L1210 and HL-60 cells), adenocarcinomic human alveolar basal epithelial cells A549 and cervical cancer cells HeLa (Jantová et al ., 2016a,b). On the other hand, this agent did not display massive cytotoxicity on mouse non-cancer fibroblast cells NIH-3T3 (Jantová et al ., 2010; Jantová et al ., 2011; Barbieriková et al ., 2011a; Barbieriková et al ., 2011b; Barbieriková et al ., 2013).…”

Section: Discussionmentioning

confidence: 97%

“…The non-photoactivated and photoactivated 7-acetyl-6,9-dihydro-6-oxo-[1,2,5]selenadiazolo[3,4-h] quinoline (derivative E2 h ) exhibited the highest cytotoxicity/phototoxicity on selected cell lines (Jantová et al ., 2010; Jantová et al ., 2016a; Barbieriková et al ., 2011a; 2011b; 2013). …”

Section: Introductionmentioning

confidence: 99%

Original Article. Study of the cytotoxic/toxic potential of the novel anticancer selenodiazoloquinolone on fibroblast cells and 3D skin model

Jantová

Topoľská

Janošková

et al. 2016

Interdisciplinary Toxicology

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The new synthetically prepared quinolone derivative 7-ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate (E2h) showed in our previous study cytotoxic effects towards tumor cells and immunomodulatory activities on RAW 264.7 cell line murine macrophages. E2h may have a potential use as a novel chemotherapeutic agent with immunomodulatory properties and the ability to induce apoptotic death of cancer cells. The aim of the present study was to examine the antiproliferative/cytotoxic activities of E2h on human non-cancer fibroblast BHNF-1 cells and reconstructed human epidermis EpiDerm™. Further the effects of E2h on tissue structure and morphology were examined. Cytotoxic/toxic studies showed that selenadiazoloquinolone is not toxic on normal human fibroblast cells BHNF-1 and dimensional skin constructs EpiDerm™. Evaluation of morphological changes in EpiDerm™ showed no change in the construction and morphology of skin tissue treated by E2h compared to control.

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“…One of these derivatives (G-1103) was also demonstrated to cause cell cycle arrest in G 2 /M phase and apoptosis in human HeLa and fibrosarcoma cells . A 1,2,5-selenadiazole derived quinolone ( VIII-60 in Figure ) presented good antiproliferative activity in HeLa cells through apoptosis induction, which improved when irradiated with ultraviolet A (UVA) light . The same compound also exhibited high antiproliferative activity in leukemia cells and immunomodulatory effect on murine cell lines …”

Section: 25-selenadiazolesmentioning

confidence: 99%

Development and Therapeutic Potential of Selenazo Compounds

et al. 2019

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Incorporation of selenium (Se) atom into small molecules can substantially enhance their antioxidant, antiinflammatory, antimutagenic, antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprotective effects. Specifically, selenazo compounds have received great attention owing to their chemical properties, pharmaceutical applications, and low toxicity. In this Perspective, we compile extensive literature evidence with the description and discussion of the most recent advances in different selenazo and selenadiazo motifs as potential pharmacological candidates. We also provide some perspectives on the challenges and future directions in the advancement of these selenazo compounds, each of which could generate drug candidates for various diseases.

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Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation

Cited by 6 publications

References 59 publications

Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation

Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation

Original Article. Study of the cytotoxic/toxic potential of the novel anticancer selenodiazoloquinolone on fibroblast cells and 3D skin model

Development and Therapeutic Potential of Selenazo Compounds

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