2016
DOI: 10.1016/j.tiv.2016.02.012
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Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation

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Cited by 6 publications
(6 citation statements)
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“…How is enoxacin activated by UVA irradiation? Previously, the phototoxicity of another new quinolone was thought to be due to ROS generation by UV exposure; however, the details underlying this remain unknown (13). Therefore, we investigated the effects of histidine and NaN3 as scavengers of singlet oxygen, mannitol as a scavenger of hydroxy radical, and SOD as a scavenger of superoxide anion on apoptosis induced by enoxacin with UVA irradiation (11,12).…”
Section: Discussionmentioning
confidence: 99%
“…How is enoxacin activated by UVA irradiation? Previously, the phototoxicity of another new quinolone was thought to be due to ROS generation by UV exposure; however, the details underlying this remain unknown (13). Therefore, we investigated the effects of histidine and NaN3 as scavengers of singlet oxygen, mannitol as a scavenger of hydroxy radical, and SOD as a scavenger of superoxide anion on apoptosis induced by enoxacin with UVA irradiation (11,12).…”
Section: Discussionmentioning
confidence: 99%
“…Cytotoxic tests showed that derivative E2 h evoked significant cytotoxic activity towards leukemia cell lines (L1210 and HL-60 cells), adenocarcinomic human alveolar basal epithelial cells A549 and cervical cancer cells HeLa (Jantová et al ., 2016a,b). On the other hand, this agent did not display massive cytotoxicity on mouse non-cancer fibroblast cells NIH-3T3 (Jantová et al ., 2010; Jantová et al ., 2011; Barbieriková et al ., 2011a; Barbieriková et al ., 2011b; Barbieriková et al ., 2013).…”
Section: Discussionmentioning
confidence: 97%
“…The non-photoactivated and photoactivated 7-acetyl-6,9-dihydro-6-oxo-[1,2,5]selenadiazolo[3,4-h] quinoline (derivative E2 h ) exhibited the highest cytotoxicity/phototoxicity on selected cell lines (Jantová et al ., 2010; Jantová et al ., 2016a; Barbieriková et al ., 2011a; 2011b; 2013). …”
Section: Introductionmentioning
confidence: 99%
“…One of these derivatives (G-1103) was also demonstrated to cause cell cycle arrest in G 2 /M phase and apoptosis in human HeLa and fibrosarcoma cells . A 1,2,5-selenadiazole derived quinolone ( VIII-60 in Figure ) presented good antiproliferative activity in HeLa cells through apoptosis induction, which improved when irradiated with ultraviolet A (UVA) light . The same compound also exhibited high antiproliferative activity in leukemia cells and immunomodulatory effect on murine cell lines …”
Section: 25-selenadiazolesmentioning
confidence: 99%