PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis
Minghua Su,
Feng Chen,
Dong Han
et al.
Abstract:Severe acute pancreatitis (SAP) is a highly fatal abdominal
emergency,
and its association with protein arginine methyltransferase 7 (PRMT7),
the sole known type III enzyme responsible for the monomethylation
of arginine residue, remains unexplored. In this study, we observe
an increase in the PRMT7 levels in the pancreas of SAP mice and Cerulein-LPS-stimulated
AR42J cells. Overexpression of Prmt7 exacerbated pancreatic damage
in SAP, while the inhibition of PRMT7 improved SAP-induced pancreatic
damage. Furthe… Show more
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