PRMT4-mediated arginine methylation promotes tyrosine phosphorylation of VEGFR-2 and regulates filopodia protrusions

Hartsough, Edward J.; Shelke, Rajani; Amraei, Razie; Aryan, Zahra; Lotfollahzadeh, Saran

doi:10.1016/j.isci.2022.104736

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…HEK-293 and 3T3-L1 cells were maintained in DMEM medium containing 10% fetal bovine serum supplemented with penicillin and streptomycin. HEK-293 cells stably expressing Minar2 were transfected with raptor construct or other plasmids as indicated in the figure legends via PEI (polyethylenimine) as described [ 15 ]. After 48 h transfection, cells were lysed and subjected to immunoprecipitation or western blotting as described in the figure legends.…”

Section: Methodsmentioning

confidence: 99%

Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity

Lotfollahzadeh

Xia

Amraei

et al. 2023

Molecular Metabolism

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Section: Methodsmentioning

confidence: 99%

Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity

Lotfollahzadeh

Xia

Amraei

et al. 2023

Molecular Metabolism

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“…VEGF exerts its angiogenic effects through two primary tyrosine kinase receptors (RTKs), namely VEGFR-1 (which regulates, VEGF receptor) and VEGFR-2 (which controls angiogenic activity). These receptors collectively influence angiogenesis in the organism [18,91] . Recognizing its critical role in in vivo angiogenesis, VEGF has emerged as a key target for the treatment of neovascular ophthalmopathies.…”

Section: Vegf-related Drugsmentioning

confidence: 99%

Advancements in Neovascular Ophthalmopathy: Therapeutic Strategies and Future Prospects

Zhang,

Lu,

et al. 2023

Preprint

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Abnormal ocular angiogenesis is a key factor in the development of many blinding ocular diseases, including wet age-related macular degeneration (wAMD), diabetic macular oedema (DME), pathologic myopia with choroidal neovascularization (PM-CNV), and neovascular glaucoma (NVG). The development of anti-neovascular drugs and ocular drug delivery systems (DDS) offers more possibilities for the treatment of neovascular eye diseases. In addition to anti-vascular endothelial growth factor (anti-VEGF) agents, the discovery of other anti-angiogenic targets, such as somatostatin, endostatin and pigment epithelium-derived factor (PEDF), has been a boon to patients with poor anti-VEGF efficacy and led to a reduction in the adverse effects of long-term VEGF inhibition. Gene therapy is currently a very promising approach for the treatment of neovascular ophthalmopathy. The rapid development of gene therapy and the potential for viral vector-mediated gene delivery to achieve sustained expression of anti-vascular substances at the lesion site will mitigate the risks associated with frequent intraocular injections for patients. This review provides an overview of several neovascular ophthalmopathies, discusses the use of anti-vascular therapeutic agents and common DDS, and summarizes treatment strategies and future perspectives for neovascular ophthalmopathy.

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VEGF signaling: Role in angiogenesis and beyond

Shaw,

Dwivedi,

Bhattacharya

et al. 2024

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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PRMT4-mediated arginine methylation promotes tyrosine phosphorylation of VEGFR-2 and regulates filopodia protrusions

Cited by 3 publications

References 44 publications

Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity

Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity

Advancements in Neovascular Ophthalmopathy: Therapeutic Strategies and Future Prospects

VEGF signaling: Role in angiogenesis and beyond

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