PRMT2 interacts with splicing factors and regulates the alternative splicing of
            <i>BCL-X</i>

Vhuiyan, Mynol I.; Pak, Magnolia L.; Park, Margaret A.; Thomas, Dylan; Lakowski, Ted M.; Chalfant, Charles E.; Frankel, Adam

doi:10.1093/jb/mvw102

Cited by 19 publications

(17 citation statements)

References 44 publications

(44 reference statements)

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“…However, PRMT2 is known to promote apoptosis via NF-κB dependent mechanism in which NF-κB transcription is inhibited, preventing IκB-α from leaving the nucleus, resulting in increased levels of nuclear IκB-α and decreased NF-κB binding to DNA [ 40 ]. PRMT2 is known to interact with a multitude of splicing factors and splicing-related proteins, and other interactions are possible [ 41 ]. Hou et al revealed a role for PRMT2 in dendrite arborization by promoting methylation of the actin nucleator, Cobl [ 42 ].…”

Section: Functional Significance Of Arginine Methylationmentioning

confidence: 99%

Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies

Bryant

Heiss

Banasavadi-Siddegowda

2021

Cells

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Protein arginine methylation is a common post-translational modification that plays a pivotal role in cellular regulation. Protein arginine methyltransferases (PRMTs) catalyze the modification of target proteins by adding methyl groups to the guanidino nitrogen atoms of arginine residues. Protein arginine methylation takes part in epigenetic and cellular regulation and has been linked to neurodegenerative diseases, metabolic diseases, and tumor progression. Aberrant expression of PRMTs is associated with the development of brain tumors such as glioblastoma and medulloblastoma. Identifying PRMTs as plausible contributors to tumorigenesis has led to preclinical and clinical investigations of PRMT inhibitors for glioblastoma and medulloblastoma therapy. In this review, we discuss the role of arginine methylation in cancer biology and provide an update on the use of small molecule inhibitors of PRMTs to treat glioblastoma, medulloblastoma, and other cancers.

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Section: Functional Significance Of Arginine Methylationmentioning

confidence: 99%

Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies

Bryant

Heiss

Banasavadi-Siddegowda

2021

Cells

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“…For example, the Bcl-x gene can generate two isoforms as a result of alternative splicing. The short protein Bcl-xS is pro-apoptotic, while the large protein Bcl-xL is anti-apoptotic ( 21 ).The alternative splicing of Bcl-x can be regulated by both protein arginine methyltransferase 2 (PRMT2) and polypyrimidine tract-binding protein 1 (PTBP1) ( 19 , 208 ). In the failing heart, the expression of Bcl-xL mRNA is significantly increased after ventricular assist device implantation ( 14 ).…”

Section: Functional Impact Of Alternative Mrna Splicing In Heartmentioning

confidence: 99%

mRNA Metabolism in Cardiac Development and Disease: Life After Transcription

Gao

Wang

2020

Physiological Reviews

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The central dogma of molecular biology illustrates the importance of mRNAs as critical mediators between genetic information encoded at the DNA level and proteomes/metabolomes that determine the diverse functional outcome at the cellular and organ levels. Although the total number of protein-producing (coding) genes in the mammalian genome is ~20,000, it is evident that the intricate processes of cardiac development and the highly regulated physiological regulation in the normal heart, as well as the complex manifestation of pathological remodeling in a diseased heart, would require a much higher degree of complexity at the transcriptome level and beyond. Indeed, in addition to an extensive regulatory scheme implemented at the level of transcription, the complexity of transcript processing following transcription is dramatically increased. RNA processing includes post-transcriptional modification, alternative splicing, editing and transportation, ribosomal loading, and degradation. While transcriptional control of cardiac genes has been a major focus of investigation in recent decades, a great deal of progress has recently been made in our understanding of how post-transcriptional regulation of mRNA contributes to transcriptome complexity. In this review, we highlight some of the key molecular processes and major players in RNA maturation and post-transcriptional regulation. In addition, we provide an update to the recent progress made in the discovery of RNA processing regulators implicated in cardiac development and disease. While post-transcriptional modulation is a complex and challenging problem to study, recent technological advancements are paving the way for a new era of exciting discoveries and potential clinical translation in the context of cardiac biology and heart disease.

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“…Serine–arginine rich (SR) splicing factors are another prominent splicing factor family [ 166 ] and it should come as no surprise that SR splicing factors are methylated due to the abundance of arginine residues they contain. The SR protein SF2A-p32 associates with PRMT1 and PRMT5 [ 167 ], while PRMT2 associates with multiple SR proteins and hnRNPs, including Sam68, to regulate alternative splicing of the mitochondrial protein Bcl-x [ 168 ]. Arginine methylation of Sam68 by PRMT1 localizes it to the cytoplasm [ 169 ] and reduces its RNA binding ability [ 170 ], thus indicating that Sam68 is highly regulated by arginine methylation.…”

Section: Protein Arginine Methylationmentioning

confidence: 99%

Protein arginine methylation: an emerging regulator of the cell cycle

Raposo¹,

Piller²

2018

Cell Div

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Protein arginine methylation is a common post-translational modification where a methyl group is added onto arginine residues of a protein to alter detection by its binding partners or regulate its activity. It is known to be involved in many biological processes, such as regulation of signal transduction, transcription, facilitation of protein–protein interactions, RNA splicing and transport. The enzymes responsible for arginine methylation, protein arginine methyltransferases (PRMTs), have been shown to methylate or associate with important regulatory proteins of the cell cycle and DNA damage repair pathways, such as cyclin D1, p53, p21 and the retinoblastoma protein. Overexpression of PRMTs resulting in aberrant methylation patterns in cancers often correlates with poor recovery prognosis. This indicates that protein arginine methylation is also an important regulator of the cell cycle, and consequently a target for cancer regulation. The effect of protein arginine methylation on the cell cycle and how this emerging key player of cell cycle regulation may be used in therapeutic strategies for cancer are the focus of this review.

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PRMT2 interacts with splicing factors and regulates the alternative splicing of BCL-X

Cited by 19 publications

References 44 publications

Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies

Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies

mRNA Metabolism in Cardiac Development and Disease: Life After Transcription

Protein arginine methylation: an emerging regulator of the cell cycle

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