Prkra is the double-stranded RNA sensor to mediate an embryonic integrated stress response
Tong Lu,
Pengcheng Ma,
Aijun Chen
et al.
Abstract:Nucleic acid sensing, the initial stage of pathogen detection, plays a fundamental role in innate immunity. Double-stranded RNAs, mainly of viral origin, are recognized by protein kinase R (PKR/Eif2ak2) in differentiated cells to trigger an integrated stress response (ISR), characterized by the inhibition of global translation. However, in pluripotent cells, the sensor of double-stranded RNAs in antiviral innate immunity is poorly defined and conflated with those in differentiated cells. In this study, we util… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.