PRKAA1 predicts prognosis and is associated with immune characteristics in gastric cancer

Abstract

PRKAA1 is the α-subunit of 5-AMP-activated protein kinase. This study aimed to investigate the role of PRKAA1 expression in multiple clinical parameters, the overall survival rate, blood indexes, and immune in ltration in gastric cancer (GC) patients. MethodsWe investigated PRKAA1 expression data of in GC patients using an ELISA, proteinatlas, ualcan, and GEPIA. PRKAA1 expression was associated with immune cell in ltration, and immune cell types were analyzed with the TIMER, DICE, and proteinatlas databases. We compared the level of PRKAA1 expression based on the clinical features of GC patients (n = 345). GC patients were divided into two groups based on PRKAA1 expression, and the lymphocyte subsets, overall survival rate, and clinical parameters were compared with peripheral blood mononuclear cell and biochemical indexes. ResultsPRKAA1 was highly expressed in the serum of GC patient compared with that of healthy individuals. GC patients with distant metastases, a later TNM stage, and stage IV in UICC exhibited higher PRKAA1 expression. PRKAA1 expression was signi cantly correlated with circulating T cells. The proteinatlas and DICE database results con rmed that PRKAA1 was closely associated with T cells in a single cell cluster. Furthermore, GC patients with low PRKAA1 expression had better OS rates. ConclusionPRKAA1 may serve as a potential prognostic biomarker for GC and have an association with immune in ltrates.