Secure aggregation is widely used in horizontal Federated Learning (FL), to prevent leakage of training data when model updates from data owners are aggregated. Secure aggregation protocols based on Homomorphic Encryption (HE) have been utilized in industrial cross-silo FL systems, one of the settings involved with privacysensitive organizations such as financial or medical, presenting more stringent requirements on privacy security. However, existing HEbased solutions have limitations in efficiency and security guarantees against colluding adversaries without a Trust Third Party. This paper proposes an efficient Doubly Homomorphic Secure Aggregation (DHSA) scheme for cross-silo FL, which utilizes multi-key Homomorphic Encryption (MKHE) and seed homomorphic pseudorandom generator (SHPRG) as cryptographic primitives. The application of MKHE provides strong security guarantees against up to N − 2 participates colluding with the aggregator, with no TTP required. To mitigate the large computation and communication cost of MKHE, we leverage the homomorphic property of SHPRG to replace the majority of MKHE computation by computationally-friendly