Privacy preserving data management in recruiting participants for digital clinical trials

Angeletti, Fabio; Chatzigiannakis, Ioannis; Vitaletti, Andrea

doi:10.1145/3144730.3144733

Cited by 20 publications

(8 citation statements)

References 18 publications

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“…Author in [15] explained about the smart contracts and blockchain technology for gaining potential benefits over process streamlines. The author manages the patient's record and has the efficiency to diminish the loss and to eliminate data fabrication by securing data over the ledgers.…”

Section: Fig 1: Generic View Of Ethereum In Block Chain Technology (Smentioning

confidence: 99%

Ethereum Blockchain Framework for Healthcare Applications

Sri¹

2021

ITII

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Block chain technology (BT) is an evolving technology with reliable and protective measured for sharing data in various applications. This work concentrates on healthcare based BT over Ethereum platform for data management. The medical applications include complex medical procedures with clinical and surgical trials. It includes managing and accessing of huge medical data. With the execution of medical applications factors like system cost are estimated for providing feasibility. This works provide multiple flows of healthcare BT over Ethereum platform. The performance of this model is analyzed with multiple flows. The data management, security, identity, and autonomy are considered as an essential factor.

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Section: Fig 1: Generic View Of Ethereum In Block Chain Technology (Smentioning

confidence: 99%

Ethereum Blockchain Framework for Healthcare Applications

Sri¹

2021

ITII

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“…Some of the trials need more than thousand patients where each must satisfy the criteria defined in the protocol. It has stated that 80% of the clinical studies are postponed because of recruitment issues [38]. Hence, delayed recruitment period extends the lifetime of the trial which consequently delays the chances of new drugs to be available in the market, thereby causing patients to wait for years until new treatment opportunities are made available.…”

Section:  Patient Recruitmentmentioning

confidence: 99%

“…This current blockchain technology (Ethereum) strengthens trust among different parties including sponsors, clinical sites and patients, thereby guaranteeing that trial standards and patient safety are not compromised [40]. Another proposed solution shows that significant results in the digital health sector can be obtained by merging IoT and blockchain technologies [38] [41]. The IoT devices enable patients to generate a massive amount of data that can be uploaded to clinical sites that help in prescreening the potential participants according to defined inclusion and exclusion criteria.…”

Section:  Patient Recruitmentmentioning

confidence: 99%

Applications of Blockchain Technology in Clinical Trials: Review and Open Challenges

et al. 2020

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Blockchain technology has disclosed unprecedented opportunities in the healthcare sector by unlocking the true value of interoperability. Specifically, the striking features of blockchain technology, such as data provenance, transparency, decentralized transaction validation, and immutability can help to compensate for stringent data management issues (e.g., patient recruitment, persistent monitoring, data management, and data analytics and accurate reporting) in clinical trials (CTs). Although several research studies show that blockchain solutions help to improve patient retention, data integrity, privacy, and ensure CTs compliance with regulatory policies, a comprehensive survey on this topic is lacking. In this survey, we provide insights into the adoption of blockchain technology in CTs. We categorize and classify the literature by devising a meticulous taxonomy of the decentralized tasks of CT and practices based on indispensable parameters. Furthermore, we provide insights on works in progress towards deploying blockchain solutions in CTs. Finally, we identify and discuss several challenges that hinder the successful implementation of blockchain technologies in CTs.

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“…Another interesting field are healthcare services logistics, including medical insurance transactions [ 31 ] and drug supply [ 32 ]. Furthermore, blockchain technology can also be applied in clinical trial management, with emphasis on participant consent management [ 33 ] and privacy preservation [ 34 ]. To the best of our knowledge, there is no other work exploiting blockchain technology for managing biomedical evidence data integrity and non-repudiation, other than the preliminary presentation of the proof of concept [ 6 ] of the solution described in this paper.…”

Section: Background and Related Workmentioning

confidence: 99%

A Blockchain-Based Notarization Service for Biomedical Knowledge Retrieval

Kleinaki

Mytis-Gkometh

Drosatos

et al. 2018

Computational and Structural Biotechnology Journal

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Biomedical research and clinical decision depend increasingly on scientific evidence realized by a number of authoritative databases, mostly public and continually enriched via peer scientific contributions. Given the dynamic nature of biomedical evidence data and their usage in the sensitive domain of biomedical science, it is important to ensure retrieved data integrity and non-repudiation. In this work, we present a blockchain-based notarization service that uses smart digital contracts to seal a biomedical database query and the respective results. The goal is to ensure that retrieved data cannot be modified after retrieval and that the database cannot validly deny that the particular data has been provided as a result of a specific query. Biomedical evidence data versioning is also supported. The feasibility of the proposed notarization approach is demonstrated using a real blockchain infrastructure and is tested on two different biomedical evidence databases: a publicly available medical risk factor reference repository and on the PubMed database of biomedical literature references and abstracts.

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Privacy preserving data management in recruiting participants for digital clinical trials

Cited by 20 publications

References 18 publications

Ethereum Blockchain Framework for Healthcare Applications

Ethereum Blockchain Framework for Healthcare Applications

Applications of Blockchain Technology in Clinical Trials: Review and Open Challenges

A Blockchain-Based Notarization Service for Biomedical Knowledge Retrieval

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