Privacy in Confidential Administrative Micro Data

Hochfellner, Daniela; Müller, Dana; Schmucker, Alexandra

doi:10.1177/1556264614552799

Cited by 8 publications

(4 citation statements)

References 14 publications

(15 reference statements)

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“…The similarity of proteins between each two biological replicates was assessed using the Spearman’s rank correlation coefficient. Hierarchical clustering of proteins was performed using Euclidean distances in the ‘pheatmap’ package (1.0.12) ( Hochfellner et al, 2014 ). PCA analysis was done using the FactoMineR package (1.3.4) ( Jombart, 2008 ).…”

Section: Methodsmentioning

confidence: 99%

The Active Constituent From Gynostemma Pentaphyllum Prevents Liver Fibrosis Through Regulation of the TGF-β1/NDRG2/MAPK Axis

et al. 2020

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Liver fibrosis resulting from chronic liver damage constitutes a major health care burden worldwide; however, no antifibrogenic agents are currently available. Our previous study reported that the small molecule NPLC0393 extracted from the herb Gynostemma pentaphyllum exerts efficient antifibrotic effects both in vivo and in vitro . In this study, a TMT-based quantitative proteomic study using a carbon tetrachloride (CCl 4 )-induced mouse model of liver fibrosis was performed to identify the potential target of NPLC0393. Combining this study with bioinformatic analysis of differentially expressed proteins between the CCl 4 model and NPLC0393 treatment groups, we focused on the function of N-myc downstream-regulated gene 2 (NDRG2) involved in cell differentiation. In vitro studies showed that NPLC0393 prevented the TGF-β1 stimulation-induced decrease in the NDRG2 level in hepatic stellate cells (HSCs). Functional studies indicated that NDRG2 can inhibit the activation of HSCs by preventing the phosphorylation of ERK and JNK. Furthermore, knockdown of NDRG2 abolished the ability of NPLC0393 to inhibit HSC activation. In conclusion, these results provide information on the mechanism underlying the antifibrotic effect of NPLC0393 and shed new light on the potential therapeutic function of the TGF-β1/NDRG2/MAPK signaling axis in liver fibrosis.

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Section: Methodsmentioning

confidence: 99%

The Active Constituent From Gynostemma Pentaphyllum Prevents Liver Fibrosis Through Regulation of the TGF-β1/NDRG2/MAPK Axis

et al. 2020

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“…To protect the privacy of persons and establishments included in the data of the RDC-IAB, access is governed by strict data protection laws. Hence, the RDC-IAB has developed a data disclosure portfolio to provide these sensitive data to external users [37]. The RDC-IAB follows the approach by Lane, Heus [38], which is based on principles of data providers worldwide.…”

Section: Privacy By Design: the Data Disclosure Portfoliomentioning

confidence: 99%

“…The aim of the disclosure control is to ensure that the released results are absolutely anonymous and that no conclusions can be drawn about individual persons or establishments. A detailed description of the procedure can be found in [37]. Figure 2 shows the relationship between the degree of anonymity and the data access types at the RDC-IAB.…”

Section: Privacy By Design: the Data Disclosure Portfoliomentioning

confidence: 99%

The Research Data Centre of the German Federal Employment Agency at the Institute for Employment Research (RDC-IAB)

Antoni

Schmucker

2019

IJPDS

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Since 2004, the Research Data Centre of the German Federal Employment Agency at the Institute for Employment Research (RDC-IAB) has been offering comprehensive individual data on employees, unemployed persons, job seekers and participants in active labour market programmes for scientific labour market research. For this purpose, data from employer notifications and from different administrative processes in the labour market administration are linked. These administrative data are also combined with survey data. In addition, linked employer-employee data allow simultaneous analyses of the supply and demand sides of the labour market. The data can be linked using unique identifiers, such as social insurance number, client number of the local employment agency, or establishment number. Since the foundation of the German Record Linkage Center (GRLC) in 2011, the RDC-IAB also applies methods for linking with non-unique and error-prone linkage identifiers like names, addresses and birth dates. German data protection law classifies the data offered by the RDC-IAB as highly sensitive and strictly regulates their use by external researchers. The RDC-IAB has therefore established various data access modes. Although the data can be transferred directly to research institutions in anonymised form, this procedure is generally not effective for linked data, as the loss of information due to the necessary anonymisation would be too great. For this reason, the RDC-IAB focuses on the access modes on-site use and remote data execution. In cooperation with other data centres, RDC-IAB has therefore established on-site data access at currently 16 locations worldwide.

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“…Access to these and other linked standard data sets of the FDZ is provided through the FDZ's secure infrastructure. As the administrative data of the IAB are subject to strict social security data protection (see Hochfellner et al, 2014), access to such linked data is limited to on-site use or remote access. 5 While FDZ's standard data sets can be accessed by academic researchers without any fee, this does not apply to custom-built data sets linked by the GRLC.…”

Section: Data Accessmentioning

confidence: 99%