Prism adaptation enhances activity of intact fronto-parietal areas in both hemispheres in neglect patients

Restoring abnormal aftereffects of prismatic adaptation through neuromodulation

“…These pieces of evidence concur to suggest a role of the PPC in limb reaching tasks, and in PA, particularly of the left PPC with the right hand. In 7 right-brain-damaged patients with left neglect, after a PA treatment, fMRI showed a bilateral increase of activity in the fronto-parietal areas, including the PPC, associated with a reduction of the rightward bisection bias, and an improvement of visual search (Saj et al, 2013).…”

“…A bilateral network is involved in PA, which includes two key cortical areas: the posterior parietal cortex (PPC), and the cerebellum (Chapman et al, 2010;Clower et al, 1996;Danckert et al, 2008;Luauté et al, 2006;Saj et al, 2013;Sekiyama et al, 2000).…”

Impact of Cognitive Neuroscience on Stroke Rehabilitation

“…В двух исследованиях активации у пациентов с игнорированием продемонстрировали, что призматическая адаптация повышает участие левого полушария в выполнении визуальных задач. Позитронно-эмиссионная томография показала, что благотворное влияние призматической адаптации на симптомы игнорирования коррелирует с двусто-ронней модуляцией кортикальных областей, учас-твующих в пространственном познании [101], и в последнем исследовании с использованием функци-ональной магнитно-резонансной томографии про-демонстрировали двустороннюю активацию лобно-теменных областей во время выполнения задач на разделение линии пополам и задач на визуальный поиск [102]. В обоих исследованиях принимали учас-тие 6 и 7 пациентов, и для полной оценки влияния на восприятие визуального пространства необходимы дальнейшие исследования.…”

“…A PET study has shown that the beneficial effect of prismatic adaptation on neglect symptoms correlates with bilateral modulation of cortical regions involved in spatial cognition, 101 and a recent functional magnetic resonance imaging study has shown an increase in fronto-parietal regions bilaterally during bisection and visual search tasks. 102 Both studies involved small numbers of patients (6 and 7), and further investigations are needed to assess fully the effects on the representation of visual space.…”

Self-regulation of inter-hemispheric visual cortex balance through real-time fMRI neurofeedback training

“…More direct support has been provided by manipulations that aim at modifying the activation balance between the left and right hemispheres, for example by caloric vestibular stimulation (Bottini et al, 2001;Geminiani and Bottini, 1992), neck vibration (Bottini et al, 2001;Schindler et al, 2002), prism adaptation (Saj et al, 2013), or transcranial magnetic stimulation (TMS) (Kim et al, 2013;Muri et al, 2013). These manipulations alleviate neglect symptoms by partly compensating for altered interhemispheric asymmetries in spatial attention, although their effect on early sensory areas remains unresolved (Saj et al, 2013). However, these treatments are often associated with patient discomfort, and the effects are short lasting.…”