Prism Adaptation Alters Electrophysiological Markers of Attentional Processes in the Healthy Brain

Martín-Arévalo, Elisa; Laube, Inga; Koun, Éric; Farnè, Alessandro; Reilly, Karen T.; Pisella, Laure

doi:10.1523/jneurosci.1153-15.2016

Cited by 29 publications

(58 citation statements)

References 97 publications

(4 reference statements)

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“…Our results also showed that low-responder patients had a selective decrease of callosal FA in the body and genu of the corpus callosum, which mainly connect sensorimotor and prefrontal areas (Catani & Thiebaut de Schotten 2012). Martín-Arévalo et al (2016) showed that leftward PA alters transcallosal motor inhibition between the two motor cortices in the healthy brain, thus confirming the possibility that PA modulates inter-hemispheric interactions. This result suggests that PA improves left neglect by allowing left-hemisphere attentional networks to access information processed by the lesioned right hemisphere, through the callosal body and genu.…”

Section: Discussionmentioning

confidence: 55%

“…Analysis of other metrics of white matter integrity (RD, MD, AD) in clusters identified by TBSS was consistent with the FA results. Martin-Arévalo et al (2016) 39 showed that leftward PA alters transcallosal motor inhibition between the two motor cortices in the healthy brain, thus confirming the possibility that PA modulates inter-hemispheric interactions.…”

Section: Discussionmentioning

confidence: 91%

“…Neuroimaging evidence in healthy individuals showed PA-induced modulation of activity in these regions (Chapman et al, 2010;Clower et al, 1996;Crottaz-Herbette, Fornari, & Clarke, 2014;Danckert, Ferber, & Goodale, 2008;Luauté et al, 2009), together with prefrontal regions including the cingulate cortex (Danckert et al, 2008). Martín-Arévalo et al (2016) showed that leftward PA alters transcallosal motor inhibition between the two motor cortices in the healthy brain, thus suggesting the possibility that PA also modulates inter-hemispheric interactions. Also consistent with this possibility, a recent model (Clarke & Crottaz-Herbette, 2016) postulates that the inferior parietal lobule (IPL) in the left hemisphere relays left-and right-sided visual stimuli to the dorsal system bilaterally.…”

Section: Introductionmentioning

confidence: 96%

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Anatomical predictors of successful prism adaptation in chronic visual neglect

Lunven

Rode

Bourlon

et al. 2017

Preprint

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Visual neglect is a frequent and disabling consequence of right hemisphere damage. Previous evidence demonstrated a probable role of posterior callosal dysfunction in the chronic persistence of neglect signs. Prism adaptation is a non-invasive and convenient technique to rehabilitate chronic visual neglect, but it is not effective in all patients. Here we hypothesized that prism adaptation improves left neglect by facilitating compensation through the contribution of the left, undamaged hemisphere. To test this hypothesis, we assessed the relationship between prism adaptation effects, cortical thickness and white matter integrity in a group of 14 patients with unilateral right-hemisphere strokes and chronic visual neglect. Consistent with our hypothesis, patients who benefitted from prism adaptation had a thicker cortex in temporo-parietal, prefrontal and cingulate areas of the left, undamaged hemisphere.Additionally, these patients had higher microstructural integrity of the body and genu of the corpus callosum. These callosal regions connect temporo-parietal, sensorimotor and prefrontal areas. Thus, prism adaptation may ameliorate signs of left visual neglect by promoting the contribution of the left hemisphere to neglect compensation. These results support current hypotheses on the role of the healthy hemisphere in the compensation for stroke-induced, chronic neuropsychological deficits, and suggest that prism adaptation can foster this role by exploiting sensorimotor/prefrontal circuits for neglect compensation. Highlights:• Visual neglect is a disabling condition resulting from right hemisphere damage • Prism adaptation is a promising therapy, but not all patients respond • We assessed the anatomical predictors of patients' response to prism adaptation • Study of cortical thickness and white matter integrity • Importance of fronto-parietal networks in the left, healthy hemisphere for recovery • Importance of callosal connections in the genu and body for recovery

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 96%

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Anatomical predictors of successful prism adaptation in chronic visual neglect

Lunven

Rode

Bourlon

et al. 2017

Preprint

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“…Spatial attention allows us to prioritise stimuli arising from particular locations in the environment (Chun, Golomb, & Turk‐Browne, ), and thus to efficiently focus on the information relevant to current goals and behaviours (Pashler, Johnston, & Ruthruff, ). Sensorimotor adaptation to optical wedge prisms can alter the balance of attention between left and right space in healthy adults (Colent, Pisella, Bernieri, Rode, & Rossetti, ; Michel et al., ; Martín‐Arévalo et al., ; for review see Michel, ), and improve symptoms of spatial neglect after stroke (Rossetti et al., ; Newport & Schenk, ; for reviews see Jacquin‐Courtois et al., ). During prism adaptation, subjects repeatedly reach to visual targets while wearing spectacle‐mounted prisms that shift the visual field to one side (Rossetti et al., ; Ting et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, the effects of prism adaptation on spatial attention align with the direction of these persistent motor errors (also referred to as motor after‐effects); attention is biased towards the side of space to which the limb erroneously reaches. While important progress has been made in identifying the neuroanatomical components of the attention network that are affected by prism adaptation (Clarke & Crottaz‐Herbette, ; Corbetta & Shulman, ; Crottaz‐Herbette, Fornari, & Clarke, ; Martín‐Arévalo et al., ; Reichenbach, Franklin, Zatka‐Haas, & Diedrichsen, ), a number of gaps remain in our understanding about how sensorimotor adaptation and attention interact. In particular, we have limited knowledge about the core task features that drives interactions between sensorimotor adaptation and shifts in spatial attention.…”

Section: Introductionmentioning

confidence: 99%

Pushing attention to one side: Force field adaptation alters neural correlates of orienting and disengagement of spatial attention

Reuter

Mattingley

Cunnington

et al. 2018

Eur J of Neuroscience

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Sensorimotor adaptation to wedge prisms can alter the balance of attention between left and right space in healthy adults, and improve symptoms of spatial neglect after stroke. Here we asked whether the orienting of spatial attention to visual stimuli is affected by a different form of sensorimotor adaptation that involves physical perturbations of arm movement, rather than distortion of visual feedback. Healthy participants performed a cued discrimination task before and after they made reaching movements to a central target. A velocity‐dependent force field pushed the hand aside during each reach, and required participants to apply compensatory forces toward the opposite side. We used event‐related potentials (ERPs) to determine whether electroencephalography (EEG) responses reflecting orienting (cue‐locked N1) and disengagement (target‐locked P1) of spatial attention are affected by adaptation to force fields. After adaptation, the cue‐locked N1 was relatively larger for stimuli presented in the hemispace corresponding to the direction of compensatory hand force. P1 amplitudes evoked by invalidly cued targets presented on the opposite side were reduced. This suggests that force field adaptation boosted attentional orienting responses toward the side of hand forces, and impeded attentional disengagement from that side, mimicking previously reported effects of prism adaptation. Thus, remapping between motor commands and intended movement direction is sufficient to bias ERPs, reflecting changes in the orienting of spatial attention in the absence of visuo‐spatial distortion or visuo‐proprioceptive mismatch. Findings are relevant to theories of how sensorimotor adaptation can modulate attention, and may open new avenues for treatment of spatial neglect.

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Prism adaptation speeds reach initiation in the direction of the prism after-effect

Striemer

Borza

2017

Exp Brain Res

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Damage to the temporal-parietal cortex in the right hemisphere often leads to spatial neglect-a disorder in which patients are unable to attend to sensory input from their contralesional (left) side. Neglect has been associated with both attentional and premotor deficits. That is, in addition to having difficulty with attending to the left side, patients are often slower to initiate leftward vs. rightward movements (i.e., directional hypokinesia). Previous research has indicated that a brief period of adaptation to rightward shifting prisms can reduce symptoms of neglect by adjusting the patient's movements leftward, toward the neglected field. Although prism adaptation has been shown to reduce spatial attention deficits in patients with neglect, very little work has examined the effects of prisms on premotor symptoms. In the current study, we examined this in healthy individuals using leftward shifting prisms to induce a rightward shift in the egocentric reference frame, similar to neglect patients prior to prism adaptation. Specifically, we examined the speed with which healthy participants initiated leftward and rightward reaches (without visual feedback) prior to and following adaptation to either 17° leftward (n = 16) or 17° rightward (n = 15) shifting prisms. Our results indicated that, following adaptation, participants were significantly faster to initiate reaches towards targets located in the direction opposite the prism shift. That is, participants were faster to initiate reaches to right targets following leftward prism adaptation and were faster to initiate reaches to left targets following rightward prism adaptation. Overall, these results are consistent with the idea that prism adaptation can influence the speed with which a reach can be initiated toward a target in the direction opposite the prism shift, possibly through altering activity in neural circuits involved in reach planning.

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Prism Adaptation Alters Electrophysiological Markers of Attentional Processes in the Healthy Brain

Abstract: target-locked P1). This is the first electrophysiological demonstration that leftward-deviating PA in healthy subjects mimics attentional patterns typically seen in neglect patients.

Cited by 29 publications

References 97 publications

Anatomical predictors of successful prism adaptation in chronic visual neglect

Anatomical predictors of successful prism adaptation in chronic visual neglect

Pushing attention to one side: Force field adaptation alters neural correlates of orienting and disengagement of spatial attention

Prism adaptation speeds reach initiation in the direction of the prism after-effect

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