Prise en charge du mélanome cutané

Thomas, Leno; Aj, Cochran

doi:10.1016/s1278-3218(99)80016-x

Cited by 4 publications

(2 citation statements)

References 189 publications

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“…Topographical association of melanomas with apocrine sweat glands was observed with lightly and heavily pigmented lesions, even though the distribution of melanophages was different between them. The absence of junctional melanocytic hyperplasia in these horses was apparently different to the features of human melanomas (17)(18)(19)(20). The presence of papillary and reticular dermis layers between the tumorous lesions and the epider-mis was another characteristic feature of these horse melanomas.…”

Section: Discussionmentioning

confidence: 69%

The Study of Cutaneous Melanomas in Camargue‐Type Gray‐Skinned Horses (1): Clinical–Pathological Characterization

Fleury

Bérard

Balme

et al. 2000

Pigment Cell Research

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The clinical and pathological characteristics of cutaneous melanomas occurring in Camargue-type gray-skinned horses are reported. Examination of 83 tumor-bearing horses revealed that the tumors occurred most frequently underneath the tail (93.9%) and at high rates in the peri-anal region (43.0%), the lips (33.0%), and the eyelids (24.0%), but rarely in the vulva (3.8%). Tumorous lesions were characterized by the presence of either hemispheric nodules or large infiltrated plaques, or their combinations. Microscopic examination indicated that tumorous lesions were composed mostly of melanocytes and numerous melanophages and that component cells manifested a remarkable cellular atypia with anisocytosis and anisokarinosis. Pathological examination of lesions corresponding to earlier stages of the tumors disclosed that tumor formation and its related melanogenesis occurred in close topographical association with apocrine sweat glands, but not at the dermal-epidermal junction. Larger nodules of the tumors were often composed of a concentric deposition of cell layers, each being separated by dermal components from the epidermis. Because of the absence of their tropism toward the epidermis and their multiloculation, horse melanomas are considered to be different in their pathological characteristics from human melanomas.

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Section: Discussionmentioning

confidence: 69%

The Study of Cutaneous Melanomas in Camargue‐Type Gray‐Skinned Horses (1): Clinical–Pathological Characterization

Fleury

Bérard

Balme

et al. 2000

Pigment Cell Research

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“…It has a high metastatic potential [1], and its incidence and mortality among the Caucasian population has increased markedly during the past three decades [2]. Accurate and reliable methods for the detection and grading of lesions and their extension are essential to allow early diagnosis and to evaluate new therapies, the two keys to success in tackling this important medical problem.…”

Section: Introductionmentioning

confidence: 99%

A new animal model for the imaging of melanoma: correlation of FDG PET with clinical outcome, macroscopic aspect and histological classification in Melanoblastoma-bearing Libechov Minipigs

Boisgard

Vincent‐Naulleau²,

Leplat³

et al. 2003

Eur J Nucl Med Mol Imaging

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The aim of this study was to evaluate the Melanoblastoma-bearing Libechov Minipigs (MeLiM) as an animal model of melanoma for in vivo imaging. Serial whole-body 2-deoxy-2-[(18)F]fluoro- d-glucose positron emission tomography (FDG PET) scans were conducted on five MeLiM. In order to explore different clinical stages of the tumoural lesions, each animal was scanned two to four times, at intervals of 30-155 days. PET images were analysed by a semiquantitative method based on the tumour to muscle metabolic ratio. Histology was performed on biopsies taken between or after the scans and the histological grading of the tumours was compared with the FDG uptake. The overall sensitivity of FDG PET for the detection of cutaneous melanoma was 75%; 62.5% of involved lymph nodes were positive. Sensitivity was better for tumours with vertical growth than for flat lesions. FDG PET did not detect tumours with epidermal involvement only, nor did it detect small metastatic foci. The metabolic ratio was correlated with the evolution of the melanoma. FDG PET is effective in the staging of cutaneous melanoma and the follow-up of tumoural extension and regression in Melanoblastoma-bearing Libechov Minipigs. The results obtained in this animal model correlate well with those described in human melanoma. Accordingly, this model may be useful in testing new tracers specific for melanoma and in helping to detect molecules expressed early during tumoural regression.

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Intérêt du dosage de la désoxypyridinoline urinaire dans le dépistage des métastases osseuses du mélanome

Roubille

Rerolle

Gelineau

et al. 2001

Immuno-analyse & Biologie Spécialisée

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Prise en charge du mélanome cutané

Cited by 4 publications

References 189 publications

The Study of Cutaneous Melanomas in Camargue‐Type Gray‐Skinned Horses (1): Clinical–Pathological Characterization

The Study of Cutaneous Melanomas in Camargue‐Type Gray‐Skinned Horses (1): Clinical–Pathological Characterization

A new animal model for the imaging of melanoma: correlation of FDG PET with clinical outcome, macroscopic aspect and histological classification in Melanoblastoma-bearing Libechov Minipigs

Intérêt du dosage de la désoxypyridinoline urinaire dans le dépistage des métastases osseuses du mélanome

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