Prise en charge de l’état de mal épileptique dans les conditions de pays en développement

Mbodj, I; Ndiaye, M.; Sene, F; Sow, Papa Salif; Sow, H. D.; Diagana, M.; Ip, Ndiaye; Diop, Amadou Gallo

doi:10.1016/s0987-7053(00)00203-3

Cited by 29 publications

(9 citation statements)

References 11 publications

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“…[7] A long duration of time lapse between the onset of seizures and treatment was observed in a retrospective data from developing country and a high mortality was reported in this study. [11] Delorenzo et al . reported a higher mortality rate when SE lasted for more than 30 minutes.…”

Section: Discussionmentioning

confidence: 99%

Predictors of outcome in children with status epilepticus during resuscitation in pediatric emergency department: A retrospective observational study

Santhanam

Yoganathan

Sivakumar

et al. 2017

Ann Indian Acad Neurol

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Objectives:To study the clinical profile and predictors of outcome in children with status epilepticus (SE) during resuscitation in pediatric emergency department.Materials and Methods:This retrospective study was carried out in a tertiary care teaching hospital. Admission and resuscitation data of children, aged between 1 month and 12 years, treated for SE, between September 2013 and August 2014, were extracted using a standard data collection form. Our SE management protocol had employed a modified pediatric assessment triangle to recognize and treat acute respiratory failure, cardiovascular dysfunction (CD), and subtle SE until all parameters resolved. Continuous positive airway pressure, fluid boluses based on shock etiology, inotropes, and cardiac safe anticonvulsants were the other modifications. Risk factors predicting mortality during resuscitation were analyzed using univariate and penalized logistic regression.Results:Among 610 who were enrolled, 582 (95.4%) survived and 28 (4.6%) succumbed. Grunt odds ratio (OR): 3.747 (95% confidence interval [CI]: 1.035−13.560), retractions OR: 2.429 (95% CI: 1.036−5.698), rales OR: 10.145 (95% CI: 4.027−25.560), prolonged capillary refill time OR: 3.352 (95% CI: 1.339−8.388), and shock requiring >60 mL/kg fluids OR: 2.439 (95% CI 1.040−5.721) were associated with 2−3 times rise in mortality. Inappropriate prehospital treatment and CD were the significant predictors of mortality OR: 7.82 (95% CI 2.10−29.06) and 738.71 (95% CI: 97.11−999), respectively. Resolution of CD was associated with improved survival OR: 0.02 (95% CI: 0.003−0.17).Conclusion:Appropriate prehospital management and treatment protocol targeting resolution of CD during resuscitation could reduce mortality in children with SE.

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Section: Discussionmentioning

confidence: 99%

Predictors of outcome in children with status epilepticus during resuscitation in pediatric emergency department: A retrospective observational study

Santhanam

Yoganathan

Sivakumar

et al. 2017

Ann Indian Acad Neurol

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“…In developed countries, predominant etiology is cerebrovascular disease whereas central nervous system (CNS) infections account for the majority in developing countries, varying between 20% and 67% in various studies. [ 7 8 9 ] Studies in developed resource-equipped settings have reported various trigger factors for SE in children most common of which include fever (presumed infection) in 36% of cases, change in medication (20%), no clear cause (9%), metabolic derangement (8%), congenital malformations (7%), anoxic events (5%), and a diverse array of other factors (trauma, vascular, infection, tumor, and drugs),[ 10 11 ] but these figures may not be true reflections of the proportions in resource-limited settings, such as India, where neuroinfections are so prevalent. The incidence of SE in children is in the range of 18–23 children per 100,000 child population per year.…”

Section: Introductionmentioning

confidence: 99%

Sociodemographic Profile, Semiology, and Etiology of Patients with Status Epilepticus: A Study from a Tertiary Care Hospital in North India

Qadir

Wani

Bhat

2018

Journal of Neurosciences in Rural Practice

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Background and Objectives:Despite advance in treatment of status epilepticus (SE), a major neurological emergency, it is still associated with mortality and morbidity. The objective of our study was to estimate sociodemographic profile, semiology, and etiology in the children with SE admitted in pediatric intensive care.Materials and Methods:Children between 1 month and 18 years with continuous seizure activity of >5 min or two or more sequential seizures without full recovery of consciousness between seizures, admitted in the Pediatric Intensive Care Unit of the Department of Pediatrics, Government Medical College, Srinagar, were included in the study. A semi-structured tool was designed to record the sociodemographic details. Detailed history, clinical examination, and investigations (including neuroimaging as and when needed) were used to determine the type of seizure and etiology.Results:A total of 51 patients were included in our study. Most of the patients were <5 years with 47.10% in 1–5 years’ age group and 43.10% in >1-year age group. Males (60.80%) outnumbered females. Thirty-nine patients (76.47%) belonged to “known” or “symptomatic” group with 35 (68.60%) of them presenting with SE as their fresh seizure. Thirty-nine (76.47%) of our patients had generalized tonic–clonic seizure (GTCS) type of SE.Conclusion:Most of the children (90%) were below the age of 5 years with male predominance. Most of the patients had SE as their first seizure without prior history of seizures with GTCSs was the most frequent seizure type.

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“…Several studies also found a predominance of focal CSE [12] , [16] , [17] , [19] . However, many authors reported a predominance of generalized seizures [5] , [6] , [7] , [14] , [15] , [18] . EEG is usually recorded after complete seizure cessation.…”

Section: Discussionmentioning

confidence: 99%

“…In Brazil, CNS infections, stroke, metabolic disorders were the reported etiologies [12] . In Sub-Saharan Africa, the commonest causes reported are CNS infections, ASM modifications, metabolic disorders, and stroke [5] , [6] , [7] . Recent African and Western studies confirm the predominance of cerebrovascular causes [2] , [5] , [15] .…”

Section: Discussionmentioning

confidence: 99%

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Convulsive status epilepticus in an emergency department in Cameroon

Massi

Owona

Magnerou

et al. 2021

Epilepsy & Behavior Reports

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Prise en charge de l’état de mal épileptique dans les conditions de pays en développement

Cited by 29 publications

References 11 publications

Predictors of outcome in children with status epilepticus during resuscitation in pediatric emergency department: A retrospective observational study

Predictors of outcome in children with status epilepticus during resuscitation in pediatric emergency department: A retrospective observational study

Sociodemographic Profile, Semiology, and Etiology of Patients with Status Epilepticus: A Study from a Tertiary Care Hospital in North India

Convulsive status epilepticus in an emergency department in Cameroon

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