“…When analyzing published data, considerable heterogeneity needs to be taken into account including: (i) the absence of a consensual classification to define HR-EC; (ii) the low number of studies and their retrospective nature; and (iii) the lack of randomized controlled studies focusing specifically on HR-EC patients. This lack of unequivocal evidence is responsible for wide variations in surgical and adjuvant management of HR-EC (10,13,(19)(20)(21)(22)(23).…”