Prioritizing Zoonoses for Global Health Capacity Building—Themes from One Health Zoonotic Disease Workshops in 7 Countries, 2014–2016

Salyer, Stephanie J.; Silver, Rachel; Simone, Kerri; Behravesh, Casey Barton

doi:10.3201/eid2313.170418

Cited by 139 publications

(104 citation statements)

References 26 publications

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“…Thus, pandemic emergence is assumed to be likely to occur because of the following risk factors: human activities near wildlife, creation of animal source foods with little monitoring of employees and a poorly understood supply chain, insect and tick vectors, extreme population density, and constrained surveillance and laboratory capacity. [8][9][10] Consequently, we can hypothesise that the advent of a catastrophic outbreak involving Disease X is likely to result from the zoonotic transmission of a highly virulent RNA virus 11 from an area where a convergence of risk factors and population dynamics will result in sustained persontoperson transmission. This premise does not negate the need for measures against other types of pathogens of pandemic importance, but the work on Disease X that we have done is modelled on the development of medical countermeasures against this particular pathogen archetype.…”

Section: Personal Viewmentioning

confidence: 99%

Disease X: accelerating the development of medical countermeasures for the next pandemic

Simpson

Kaufmann

Glozman

et al. 2020

The Lancet Infectious Diseases

114

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WHO has listed several priority diseases with epidemic potential for which there are no, or insufficient, medical countermeasures. In response, the Bill & Melinda Gates Foundation (with support from PricewaterhouseCoopers) coordinated subject matter experts to create a preparedness plan for Disease X. Disease X is caused by Pathogen X, an infectious agent that is not currently known to cause human disease, but an aetiologic agent of a future outbreak with epidemic or pandemic potential. We have identified crucial areas for acceleration in medical countermeasure product development and international coordination. We have also reviewed novel platforms and process improvements related to manufacturing, which could revolutionise the response to the next pandemic. Finally, we created several coordination and engagement guides. These guides range from the rational design of an intervention target product profile, to the key facets of vaccine and therapeutic development, to accelerated manufacturing and regulatory mechanisms. In this Personal View, we provide a high-level summary of the outcomes of the medical countermeasure development workstream, intended for a broad audience including academia, medical countermeasure developers, and multilateral coordinating bodies. We hope that they might find this piece useful in prioritising strategic investments and efforts to accelerate medical countermeasure development. We observed that in-depth analyses of clinical trial design, chemistry, manufacturing and control activities, and accelerated regulatory pathways are necessary for shortening the timelines for the product development of medical countermeasures. We intend to cover these topics in future publications.

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Section: Personal Viewmentioning

confidence: 99%

Disease X: accelerating the development of medical countermeasures for the next pandemic

Simpson

Kaufmann

Glozman

et al. 2020

The Lancet Infectious Diseases

114

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show abstract

“…The participants perceived a One Heath approach to strengthen their capacity to achieve their own sectors objectives to tackle AMR by gaining new knowledge and understanding. To achieve successful multi-sectorial participation, the development of trust, transparency, equal representation and consensus amongst all relevant sectors is needed [24]. Bordier and Nguyen (2017) reported that actors working in the animal and human health sectors have found it difficult to understand each sectors' surveillance objectives, leading to a lack of mutual understanding and of the shared benefits of consistent collaboration [25].…”

Section: One Health Approachmentioning

confidence: 99%

“…Collaboration between the animal and human health sectors, as outlined in the Ministry of Agriculture and Rural Development National Action Plan is an essential component of evidence-based policy and guidelines aimed to control antibiotic use within the human health and animal health sectors and to provide information on the spread of bacterial strains and genetic determinants of resistance [23]. Multi-sectorial participation in the development of priority setting is thought to be most successful when trust, transparency, equal representation and consensus are present among all relevant sectors [24]. Within Vietnam, it is reported that key actors have found it difficult to understand the objectives of each sectors' AMR surveillance system, leading to a lack of mutual understanding of the shared benefits of consistent collaboration [25].…”

Section: Introductionmentioning

confidence: 99%

The challenges of investigating antimicrobial resistance in Vietnam - what benefits does a One Health approach offer the animal and human health sectors?

et al. 2020

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Background: The One Health concept promotes the enhancement of human, animal and ecosystem health through multi-sectorial governance support and policies to combat health security threats. In Vietnam, antimicrobial resistance (AMR) in animal and human health settings poses a significant threat, but one that could be minimised by adopting a One Health approach to AMR surveillance. To advance understanding of the willingness and abilities of the human and animal health sectors to undertake investigations of AMR with a One Health approach, we explored the perceptions and experiences of those tasked with investigating AMR in Vietnam, and the benefits a multi-sectorial approach offers. Methods: This study used qualitative methodology to provide key informants' perspectives from the animal and human health sectors. Two scenarios of food-borne AMR bacteria found within the pork value chain were used as case studies to investigate challenges and opportunities for improving collaboration across different stakeholders and to understand benefits offered by a One Health approach surveillance system. Fifteen semi-structured interviews with 11 participants from the animal and six from the human health sectors at the central level in Hanoi and the provincial level in Thai Nguyen were conducted. Results: Eight themes emerged from the transcripts of the interviews. From the participants perspectives on the benefits of a One Health approach: (1) Communication and multi-sectorial collaboration; (2) Building comprehensive knowledge; (3) Improving likelihood of success. Five themes emerged from participants views of the challenges to investigate AMR: (4) Diagnostic capacity; (5) Availability and access to antibiotics (6) Tracing ability within the Vietnamese food chain; (7) Personal benefits and (8) Managing the system. Conclusion: The findings of this study suggest that there is potential to strengthen multi-sectorial collaboration between the animal and human health sectors by building upon existing informal networks. Based on these results, we recommend an inclusive approach to multi-sectorial communication supported by government network activities to facilitate partnerships and create cross-disciplinary awareness and participation. The themes relating to diagnostic capacity show that both sectors are facing challenges to undertake investigations in AMR. Our results indicate that the need to strengthen the animal health sector is more pronounced.

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“…Several countries have conducted One Health prioritization exercises to identify their major zoonotic diseases ( 10 ), a critical step in efforts to control endemic zoonotic diseases ( 11 ). Ethiopia, the Democratic Republic of the Congo, and Georgia are all developing successful integrated zoonotic prevention and control programs ( 12 ).…”

Section: Preventmentioning

confidence: 99%

Progress and Opportunities for Strengthening Global Health Security

Angulo¹,

Cassell²,

Tappero³

et al. 2017

Emerg. Infect. Dis.

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Prioritizing Zoonoses for Global Health Capacity Building—Themes from One Health Zoonotic Disease Workshops in 7 Countries, 2014–2016

Cited by 139 publications

References 26 publications

Disease X: accelerating the development of medical countermeasures for the next pandemic

Disease X: accelerating the development of medical countermeasures for the next pandemic

The challenges of investigating antimicrobial resistance in Vietnam - what benefits does a One Health approach offer the animal and human health sectors?

Progress and Opportunities for Strengthening Global Health Security

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