2020
DOI: 10.1016/j.fsigen.2020.102376
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Prioritising family members for genotyping in missing person cases: A general approach combining the statistical power of exclusion and inclusion

Abstract: Missing person identification typically involves genetic matching of a person of interest against relatives of the missing person. In cases with few available relatives, exhumations or other substantial efforts may be necessary in order to secure adequate statistical power. We propose a simulation approach for solving prioritisation problems arising in such cases. Conditioning on the already typed individuals we estimate the power of each alternative, both to detect the true person, and to exclude false candid… Show more

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Cited by 21 publications
(20 citation statements)
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“…1.000 V 3 0.996 0.004 V 4 1.000 V 5 1.000 V 6 1.000 V 7 1.000 V 8 1.000 Table 9. Posterior pairing probabilities in the plane crash example calculated using a flat prior and a proportional mutational model with rate 0.001.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…1.000 V 3 0.996 0.004 V 4 1.000 V 5 1.000 V 6 1.000 V 7 1.000 V 8 1.000 Table 9. Posterior pairing probabilities in the plane crash example calculated using a flat prior and a proportional mutational model with rate 0.001.…”
Section: Discussionmentioning
confidence: 99%
“…6.75e-02 6.79e+04 6.66e-02 V 3 1.03e-04 3.82e-03 V 4 3.78e-05 3.19e+07 V 5 9.62e-04 3.92e-03 V 6 1.08e+06 1.29e-05 V 7 5.90e-04 1.90e-01 V 8 1.91e-04 2.72e-01 Table 6. Pairwise LRs for the plane crash example.…”
Section: A Comparison Of Methodsmentioning
confidence: 99%
“…Familial searching and kinship analysis, section 'Investigation Using Autosomal STR Profiles', may be used when there is prior information (e.g. clothing, tattoos, passenger records, identification by relatives) suggesting a potential identity for the remains [47]. Forensic genealogy, section 'Forensic Genealogy', is also being used, e. g. the DNA Doe project [48] and The Centre for Human Identification [49] in the U.S.A.…”
Section: Body Identificationmentioning
confidence: 99%
“…Ultimately, however, the same threshold is applied to every kinship DNA case, regardless of the available pedigree. When performing DNA kinship matching, the weight of the DNA evidence is obviously increased by adding as many close relatives as possible to the pedigree or by performing pair-wise searches [29][30][31]. The reality is that the best scenario to support the identification may not be feasible as it depends directly on which relatives were selected and were available to have their DNA collected at the time of the investigation, which can date back several decades.…”
Section: Introductionmentioning
confidence: 99%