Priorities for Broadening the Malaria Vector Control Tool Kit

Barreaux, Priscille; Barreaux, Antoine M. G.; Sternberg, Eleanore D.; Suh, Eunho; Waite, Jessica L.; Whitehead, Shelley A.; Thomas, Matthew B.

doi:10.1016/j.pt.2017.06.003

Cited by 54 publications

(55 citation statements)

References 98 publications

(97 reference statements)

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“…Similar ambitious targets are set out in the Aspiration to Action document prepared by the Bill and Melinda Gates Foundation. The requirement for supplementary tools to be implemented at scale within the next 5 years to avert an anticipated rebound in malaria (due to waning natural immunity and potential impacts of insecticide resistance) puts an emphasis on approaches that are close to field‐ready, and limits the immediate utility of prospective tools that are still far from operational . An alternative to waiting for gene drive systems to be perfected and approved is to genetically engineer microbes that associate with mosquitoes.…”

Section: Introductionmentioning

confidence: 99%

“…The requirement for supplementary tools to be implemented at scale within the next 5 years to avert an anticipated rebound in malaria (due to waning natural immunity and potential impacts of insecticide resistance) puts an emphasis on approaches that are close to field-ready, and limits the immediate utility of prospective tools that are still far from operational. 15 An alternative to waiting for gene drive systems to be perfected and approved is to genetically engineer microbes that associate with mosquitoes. Pantoea agglomerans bacteria have been engineered to express an anti-malarial transgene; this species occurs naturally in mosquitoes and is passed from female to offspring.…”

Section: Introductionmentioning

confidence: 99%

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A review of progress toward field application of transgenic mosquitocidal entomopathogenic fungi

Lovett

Bilgo

Diabaté

et al. 2019

Pest Management Science

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In Africa, adult mosquito populations are primarily controlled with insecticide‐impregnated bed nets and residual insecticide sprays. This coupled with widespread applications of pesticides in agriculture has led to increasing insecticide resistance in mosquito populations. We have developed multiple alternative strategies for exploiting transgenic Metarhizium spp. directed at: (i) shortening the lifespan of adult mosquitoes; (ii) reducing transmission potential of Plasmodium spp.; (iii) reducing vector competence via pre‐lethal effects. The present challenge is to convert this promising strategy into a validated public health intervention by resolving outstanding issues related to the release of genetically modified organisms. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A review of progress toward field application of transgenic mosquitocidal entomopathogenic fungi

Lovett

Bilgo

Diabaté

et al. 2019

Pest Management Science

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“…Vector control efforts mainly aim at eliminating man-vector contact [6] The most widely embraced options for this purpose are the large-scale use of long-lasting insecticidetreated nets (LLINs), and the application of indoor residual spraying (IRS) [6,7]. The two insecticidebased methods although regarded as being among the key factors that contributed to 50%-60% reduction of malaria globally from 2000 to 2015 are faced with serious challenges related to insecticide resistance in vector populations and availability of the necessary funding to support malaria control programmes [8,9,10,11]. The World Health Organization's response to these perennial challenges includes the promotion of integrated vector management (IVM), involving the combining of existing primary interventions of LLINs and IRS with complementary methods such as house improvements and other environmental management measures [12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Evaluating effectiveness of screening house eaves as an intervention for integrated vector management for malaria control in Nyabondo, Western Kenya.

Ng’ang’a

Okoyo

Mbogo

et al. 2019

Preprint

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BackgroundMosquito-proofing of houses with appropriate screens fixed at potential mosquito entry points is gaining greater recognition as a practical intervention for reducing malaria transmission indoors. The study aimed at evaluating the effectiveness of house eaves screening in preventing mosquito entry and malaria prevalence in Nyabondo, western Kenya. Methods160 houses were selected for the study, with half of them randomly chosen for screening at the eaves with fibre-glass coated wire mesh (experimental group) and the other half left without screening (control group). Randomization was carried out by use of computer-generated list, in permuted blocks of ten houses and 16 village blocks in the study site, with treatments in the ratio of 1:1. Cross-sectional baseline entomological and malaria parasitological data were collected before house eave screening. After the baseline period, series of sampling of indoor adult mosquitoes were conducted once a month in each village using CDC light traps. Three cross-sectional malaria parasitological surveys were also conducted at three month intervals after installation of the screens. The primary outcome measures were indoor Anopheles mosquito density and malaria parasite prevalence. ResultsA total of 15,286 mosquitoes were collected over the two years period using CDC light trap in 160 houses distributed over 16 study villages (mean = 4.35, SD = 11.48). Of all mosquitoes collected, 2,872 were anophelines (2,869 An. gambiae s.l., 1 An. funestus and 2 other anopheles). Overall, among An. gambiae collected, 92.6% were non-blood fed, 3.57% were blood fed and the remaining 0.47% were composed of gravid and half gravid females. Overall more mosquitoes were collected in the control than experimental arms of the study. Results from four cross-sectional prevalence surveys showed that screened houses recorded relatively low malaria prevalence rates compared to the control houses. Overall, malaria prevalence was 5.6% (95%CI: 4.2-7.5) N=1,918, with baseline survey recording 6.1% prevalence (95%CI: 3.9-9.4), n=481 and third follow-up survey recording 3.6% prevalence (95%CI: 2.0-6.8) n=494. At all the three follow-up survey points, house screening significantly reduced the malaria prevalence by 100% (p<0.001), 63.6% (p=0.026), and 100% (p<0.001) for first, second and third follow-ups surveys respectively. The house screening significantly reduced malaria prevalence by 54% (OR = 0.46, 95%CI: 0.24-0.87, p = 0.017). ConclusionsThe study demonstrated that house eave screening has potential to reduce indoor vector densities and malaria transmission in high transmission areas in Kenya.

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“…For example, mosquitos can bite when people are not sleeping (Guerin et al, 2002), and mosquitoes have shown increased resistance to existing insecticides (Ranson & Lissenden, 2016). New tools for malaria prevention are needed in many settings (Barreaux et al, 2017). …”

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confidence: 99%

Integrating Models of Diffusion and Behavior to Predict Innovation Adoption, Maintenance, and Social Diffusion

Smith

Kim

Zhu

et al. 2018

Journal of Health Communication

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This study documents an investigation into the adoption and diffusion of eave tubes, a novel mosquito vector control, during a large-scale scientific field trial in West Africa. The diffusion of innovations (DOI) and the integrated model of behavior (IMB) were integrated (i.e., innovation attributes with attitudes and social pressures with norms) to predict participants’ (N = 329) diffusion intentions. The findings showed that positive attitudes about the innovation’s attributes were a consistent positive predictor of diffusion intentions: adopting it, maintaining it, and talking with others about it. As expected by the DOI and the IMB, the social pressure created by a descriptive norm positively predicted intentions to adopt and maintain the innovation. Drawing upon sharing research, we argued that the descriptive norm may dampen future talk about the innovation, because it may no longer be seen as a novel, useful topic to discuss. As predicted, the results showed that as the descriptive norm increased, the intention to talk about the innovation decreased. These results provide broad support for integrating the DOI and the IMB to predict diffusion and for efforts to draw on other research to understand motivations for social diffusion.

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Priorities for Broadening the Malaria Vector Control Tool Kit

Cited by 54 publications

References 98 publications

A review of progress toward field application of transgenic mosquitocidal entomopathogenic fungi

A review of progress toward field application of transgenic mosquitocidal entomopathogenic fungi

Evaluating effectiveness of screening house eaves as an intervention for integrated vector management for malaria control in Nyabondo, Western Kenya.

Integrating Models of Diffusion and Behavior to Predict Innovation Adoption, Maintenance, and Social Diffusion

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