Prior viral infection determines the mode and severity of monkeypox virus

Hussain, Hussain; Paidas, Michael J.; Fadel, Aya; Ramamoorthy, Rajalakshmi; Garcia, Efrain; Saadoon, Zahraa; Casmartino, Ekaterina; Méndez, L.; Williams, Erik; Ruíz-Cordero, Roberto; Jayakumar, Arumugam R.

doi:10.1016/j.ijid.2023.03.047

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…Diverse viruses exhibit an adept capacity to infiltrate the integumentary system, specifically establishing residence within the basal layer of the epidermis. Among the notable viral entities engaging in this modus operandi are herpes simplex, vaccinia virus, molluscum contagiosum, varicella-zoster, human papillomavirus, polyomavirus, human immunodeficiency virus (HIV), Zika virus, West Nile virus, Dengue virus, Chikungunya virus, and an array of other pathogens [ 50 , 51 , 52 , 53 , 54 ]. These viruses strategically exploit the epidermal stratum as a conducive environment for their replication processes [ 50 , 51 , 52 , 53 , 54 ], with keratinocytes emerging as the principal cellular cohort for such proliferative endeavors [ 50 , 51 , 52 , 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among the notable viral entities engaging in this modus operandi are herpes simplex, vaccinia virus, molluscum contagiosum, varicella-zoster, human papillomavirus, polyomavirus, human immunodeficiency virus (HIV), Zika virus, West Nile virus, Dengue virus, Chikungunya virus, and an array of other pathogens [ 50 , 51 , 52 , 53 , 54 ]. These viruses strategically exploit the epidermal stratum as a conducive environment for their replication processes [ 50 , 51 , 52 , 53 , 54 ], with keratinocytes emerging as the principal cellular cohort for such proliferative endeavors [ 50 , 51 , 52 , 53 , 54 ]. The epidermis, a proliferative substrate, becomes the locus for the intricate orchestration of viral replication, thereby facilitating the propagation and dissemination of these viral agents [ 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

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Dermatologic Changes in Experimental Model of Long COVID

Hussain,

Paidas,

Rajalakshmi

et al. 2024

Microorganisms

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The coronavirus disease-19 (COVID-19) pandemic, declared in early 2020, has left an indelible mark on global health, with over 7.0 million deaths and persistent challenges. While the pharmaceutical industry raced to develop vaccines, the emergence of mutant severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) strains continues to pose a significant threat. Beyond the immediate concerns, the long-term health repercussions of COVID-19 survivors are garnering attention, particularly due to documented cases of cardiovascular issues, liver dysfunction, pulmonary complications, kidney impairments, and notable neurocognitive deficits. Recent studies have delved into the pathophysiological changes in various organs following post-acute infection with murine hepatitis virus-1 (MHV-1), a coronavirus, in mice. One aspect that stands out is the impact on the skin, a previously underexplored facet of long-term COVID-19 effects. The research reveals significant cutaneous findings during both the acute and long-term phases post-MHV-1 infection, mirroring certain alterations observed in humans post-SARS-CoV-2 infection. In the acute stages, mice exhibited destruction of the epidermal layer, increased hair follicles, extensive collagen deposition in the dermal layer, and hyperplasticity of sebaceous glands. Moreover, the thinning of the panniculus carnosus and adventitial layer was noted, consistent with human studies. A long-term investigation revealed the absence of hair follicles, destruction of adipose tissues, and further damage to the epidermal layer. Remarkably, treatment with a synthetic peptide, SPIKENET (SPK), designed to prevent Spike glycoprotein-1 binding with host receptors and elicit a potent anti-inflammatory response, showed protection against MHV-1 infection. Precisely, SPK treatment restored hair follicle loss in MHV-1 infection, re-architected the epidermal and dermal layers, and successfully overhauled fatty tissue destruction. These promising findings underscore the potential of SPK as a therapeutic intervention to prevent long-term skin alterations initiated by SARS-CoV-2, providing a glimmer of hope in the battle against the lingering effects of the pandemic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dermatologic Changes in Experimental Model of Long COVID

Hussain,

Paidas,

Rajalakshmi

et al. 2024

Microorganisms

Self Cite

View full text Add to dashboard Cite

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“…48 The skin pathology of Mpox patients with HCV infection is more severe than that of patients without HCV infection, but more studies are needed to investigate whether HCV will lead to breakthrough infection and reinfection of MPXV. 49 JIANG ET AL.…”

Section: Possible Immunological Reasons For Mpox Breakthrough Infecti...mentioning

confidence: 99%

Breakthrough infection and reinfection in patients with mpox

Jiang,

Hu,

Yang

et al. 2024

Reviews in Medical Virology

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Recently, patients with Mpox breakthrough infection or reinfection were constantly reported. However, the induction, risk factors, and important clinical symptoms of breakthrough infection and reinfection of Mpox virus (MPXV), as well as the factors affecting the effectiveness of Mpox vaccine are not characterized. Herein, a literature review was preformed to summarize the risk factors and important clinical symptoms of patients with Mpox breakthrough infection or reinfection, as well as the factors affecting the effectiveness of smallpox vaccine against Mpox. Results showed that MSM sexual behavior, condomless sexual behavior, multiple sexual partners, close contact, HIV infection, and the presence of comorbidity are important risk factors for Mpox breakthrough infection and reinfection. Genital ulcers, proctitis, and lymphadenopathy are the important clinical symptoms of Mpox breakthrough infection and reinfection. The effectiveness of emergent vaccination of smallpox vaccine for post‐exposure of MPXV is associated with smallpox vaccination history, interval between exposure and vaccination, and history of HIV infection. This review provides a better understanding for the risk factors and important clinical symptoms of Mpox breakthrough infection and reinfection, as well as the formulation of Mpox vaccine vaccination strategies.

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Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development

Andrei,

Snoeck

2023

Trends in Pharmacological Sciences

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Prior viral infection determines the mode and severity of monkeypox virus

Cited by 4 publications

References 33 publications

Dermatologic Changes in Experimental Model of Long COVID

Dermatologic Changes in Experimental Model of Long COVID

Breakthrough infection and reinfection in patients with mpox

Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development

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