Prior Statin Use Has No Effect on Survival After Intracerebral Hemorrhage in a Multiethnic Asian Patient Cohort

King, Nicolas Kon Kam; Tay, Vincent K S; Allen, John C.; Ang, Beng-Ti

doi:10.1007/978-3-7091-0956-4_66

Cited by 16 publications

(25 citation statements)

References 14 publications

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“…in‐hospital or at 30 or 90 days post‐discharge (OR 0.85, 95% CI 0.70–1.03; Fig. ) . A similar effect was observed when separate analyses were performed for mortality in‐hospital (OR 1.00, 95% CI 0.84–1.20; Fig.…”

Section: Resultssupporting

confidence: 65%

“…a) and at 30 days (OR 1.04, 95% CI 0.88–1.22; Fig. b) . However, pre‐ICH statin use significantly decreased 90‐day mortality (OR 0.72, 95% CI 0.59–0.88; Fig.…”

Section: Resultsmentioning

confidence: 86%

“…In the sole case of excluding the study by King et al . , a significantly different summary OR was estimated: 0.81, 95% CI 0.66–0.98.…”

Section: Resultsmentioning

confidence: 89%

“…The only study whose exclusion significantly influenced our results was that of King et al . . The summary OR after removing this study was 0.81, 95% CI 0.66–0.98, suggesting that pre‐statin use could reduce post‐ICH morality across all three time points examined.…”

Section: Discussionmentioning

confidence: 86%

See 3 more Smart Citations

Association between statin use and intracerebral hemorrhage: a systematic review and meta‐analysis

Lei

Liu

et al. 2013

Euro J of Neurology

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show abstract

Section: Resultssupporting

confidence: 65%

“…a) and at 30 days (OR 1.04, 95% CI 0.88–1.22; Fig. b) . However, pre‐ICH statin use significantly decreased 90‐day mortality (OR 0.72, 95% CI 0.59–0.88; Fig.…”

Section: Resultsmentioning

confidence: 86%

“…In the sole case of excluding the study by King et al . , a significantly different summary OR was estimated: 0.81, 95% CI 0.66–0.98.…”

Section: Resultsmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 86%

See 2 more Smart Citations

Association between statin use and intracerebral hemorrhage: a systematic review and meta‐analysis

Lei

Liu

et al. 2013

Euro J of Neurology

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“…Patients who are treated with statins prior to aSAH tend to have a lower incidence of subsequent CVS (17). However, other studies have shown that simvastatin does not exert a beneficial effect on patients with aSAH (8,9). Kramer et al (11) pointed out that if there is a benefit to statin use, it may be smaller than suggested by previous studies.…”

Section: Introductionmentioning

confidence: 97%

Effect of statins on aneurysmal subarachnoid hemorrhage: a meta-analysis of randomized controlled trials

Zhang¹,

Song²,

Wang³

et al. 2014

Turkish Neurosurgery

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AIm:The role of statins for treating aneurysmal subarachnoid hemorrhage (aSAH) remains uncertain. In this study, the relevance of different end points was evaluated in order to clarify the action and efficacy of statins. mAterIAl and methOds: A systematic literature retrieval was carried out to obtain randomized controlled trials (RCTs) from before March 2013 on the use of statins for aSAH. Data extraction and quality evaluation of the studies were performed by 2 investigators. A meta-analysis was performed using Review Manager (RevMan) software version 5.2.3. results:Seven randomized controlled trials comprising 347 patients that met the inclusion criteria were included in this meta-analysis. Results showed that, in aSAH, statins did not reduce vasospasm on transcranial Doppler (RR=0.80; 95% CI, 0.53-1.21; p=0.29) or improve outcomes (RR=0.92; 95% CI, 0.71-1.20; p=0.54). However, statins were able to decrease delayed ischemic neurological deficits (RR=0.56; 95% CI, 0.41-0.75; p=0.0001) and mortality (RR=0.54; 95% CI, 0.32-0.91; p=0.02) compared with placebo.COnClusIOn: Acute statin treatment might not be a good choice for cerebral vasospasm after aSAH. Further large-scale, well-designed RCTs on this topic are still needed. BulGulAr: Bu meta analize çalışmaya alma kriterlerini karşılayan 347 hastalık yedi randomize kontrollü çalışma dahil edilmiştir. Sonuçlar aSAK durumunda statinlerin transkraniyal Doppler'de vazospazmı azaltmadığını (RR=0,80; %95 GA, 0,21; p=0,29) veya sonuçları daha iyi hale getirmediğini (RR=0,92; %95CI, 0,20; p=0,54) göstermiştir. Ancak statinler plaseboyla karşılaştırıldığında gecikmiş iskemik nörolojik defisitleri (RR=0,56; %95 GA, 0,41-0,75; p=0,0001) ve mortaliteyi (RR=0,54; %95 GA, 0,32-0,91; p=0,02) azaltmıştır. sOnuÇ: Akut statin tedavisi aSAK sonrasında serebral vazospazm için iyi bir tercih olmayabilir. Bu konuda daha büyük ölçekli ve iyi tasarlanmış randomize kontrollü çalışmalar gereklidir.

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Statins for people with intracerebral hemorrhage

Yang

Wang

Shu

et al. 2022

Cochrane Database of Systematic Reviews

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Prior Statin Use Has No Effect on Survival After Intracerebral Hemorrhage in a Multiethnic Asian Patient Cohort

Abstract: No beneficial effect on survival after ICH of prior statin use could be demonstrated in our large multi-ethnic Asian patient cohort.

Cited by 16 publications

References 14 publications

Association between statin use and intracerebral hemorrhage: a systematic review and meta‐analysis

Association between statin use and intracerebral hemorrhage: a systematic review and meta‐analysis

Effect of statins on aneurysmal subarachnoid hemorrhage: a meta-analysis of randomized controlled trials

Statins for people with intracerebral hemorrhage

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