Abstract:The paper deals with a specification of the prior distribution of the initial state for Kalman filter. The subjective prior knowledge, used in state estimation, can be highly uncertain. In practice, incorporation of prior knowledge contributes to a good start of the filter. The present paper proposes a methodology for selection of the initial state distribution, which enables eliciting of prior knowledge from the available expert information. The proposed methodology is based on the use of the conjugate prior … Show more
“…This informed prior is provided to the CSUKF which utilizes it to uniquely estimate the parameters even in the case of non-identifiability. The CSUKF belongs to the Gaussian family, thus the conjugate prior distribution can be used to define the prior for the parameters and state variables, while maintaining the same probability density function (pdf) after transformation [ 53 ]. Lindley & El-Sayyad [ 54 ] applied a similar treatment for non-identifiable parameters, using Bayesian inference to estimate parameters with respect to linear constraints.…”
BackgroundUtilizing kinetic models of biological systems commonly require computational approaches to estimate parameters, posing a variety of challenges due to their highly non-linear and dynamic nature, which is further complicated by the issue of non-identifiability. We propose a novel parameter estimation framework by combining approaches for solving identifiability with a recently introduced filtering technique that can uniquely estimate parameters where conventional methods fail. This framework first conducts a thorough analysis to identify and classify the non-identifiable parameters and provides a guideline for solving them. If no feasible solution can be found, the framework instead initializes the filtering technique with informed prior to yield a unique solution.ResultsThis framework has been applied to uniquely estimate parameter values for the sucrose accumulation model in sugarcane culm tissue and a gene regulatory network. In the first experiment the results show the progression of improvement in reliable and unique parameter estimation through the use of each tool to reduce and remove non-identifiability. The latter experiment illustrates the common situation where no further measurement data is available to solve the non-identifiability. These results show the successful application of the informed prior as well as the ease with which parallel data sources may be utilized without increasing the model complexity.ConclusionThe proposed unified framework is distinct from other approaches by providing a robust and complete solution which yields reliable and unique parameter estimation even in the face of non-identifiability.Electronic supplementary materialThe online version of this article (doi:10.1186/s12859-015-0500-9) contains supplementary material, which is available to authorized users.
“…This informed prior is provided to the CSUKF which utilizes it to uniquely estimate the parameters even in the case of non-identifiability. The CSUKF belongs to the Gaussian family, thus the conjugate prior distribution can be used to define the prior for the parameters and state variables, while maintaining the same probability density function (pdf) after transformation [ 53 ]. Lindley & El-Sayyad [ 54 ] applied a similar treatment for non-identifiable parameters, using Bayesian inference to estimate parameters with respect to linear constraints.…”
BackgroundUtilizing kinetic models of biological systems commonly require computational approaches to estimate parameters, posing a variety of challenges due to their highly non-linear and dynamic nature, which is further complicated by the issue of non-identifiability. We propose a novel parameter estimation framework by combining approaches for solving identifiability with a recently introduced filtering technique that can uniquely estimate parameters where conventional methods fail. This framework first conducts a thorough analysis to identify and classify the non-identifiable parameters and provides a guideline for solving them. If no feasible solution can be found, the framework instead initializes the filtering technique with informed prior to yield a unique solution.ResultsThis framework has been applied to uniquely estimate parameter values for the sucrose accumulation model in sugarcane culm tissue and a gene regulatory network. In the first experiment the results show the progression of improvement in reliable and unique parameter estimation through the use of each tool to reduce and remove non-identifiability. The latter experiment illustrates the common situation where no further measurement data is available to solve the non-identifiability. These results show the successful application of the informed prior as well as the ease with which parallel data sources may be utilized without increasing the model complexity.ConclusionThe proposed unified framework is distinct from other approaches by providing a robust and complete solution which yields reliable and unique parameter estimation even in the face of non-identifiability.Electronic supplementary materialThe online version of this article (doi:10.1186/s12859-015-0500-9) contains supplementary material, which is available to authorized users.
“…• "Since the Kalman framework requires Gaussian distributions, the model can only be constructed if ... " [2] • "The Kalman filter which is used for integrated navigation requires Gaussian variables ... a multimodal un-symmetric distribution has to be approximated with a Gaussian distribution before being used in the Kalman filter." [3] • "...can be best reconciled with the KF (which requires Gaussian probability distributions) by making the assumption that ... " [4] • " [The] Kalman filter requires Gaussian prior f (x 0 ) ... " [5] • "Notice that each of the distributions can be effectively approximated by a Gaussian. This is a very important result for the operation for many systems, especially the ones based on a Kalman filter since the filter explicitly requires Gaussian distributed noise on measurements for proper operation."…”
One of the most common misconceptions made about the Kalman filter when applied to linear systems is that it requires an assumption that all error and noise processes are Gaussian. This misconception has frequently led to the Kalman filter being dismissed in favor of complicated and/or purely heuristic approaches that are supposedly ``more general'' in that they can be applied to problems involving non-Gaussian noise. The fact is that the Kalman filter provides rigorous and optimal performance guarantees that do not rely on any distribution assumptions beyond mean and error covariance information. These guarantees even apply to use of the Kalman update formula when applied with nonlinear models, as long as its other required assumptions are satisfied. Here we discuss misconceptions about its generality that are often found and reinforced in the literature, especially outside the traditional fields of estimation and control.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.