Prior intrauterine position influences body weight in male and female mice

Kinsley, Craig Howard; Miele, Joseph; Wagner, Christine K.; Ghiraldi, Loraina; Broida, John; Svare, Bruce

doi:10.1016/0018-506x(86)90018-8

Cited by 34 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of prenatal testosterone on body mass and growth is not clear. Whereas some studies have found that testosterone during the pre-natal phase retards intra-uterine growth and leads to low birth weight of females [55,56], others have found the opposite result [15,16,57] or none [58]. Given the lack of sexual dimorphism in the rabbit with respect to birth mass and growth, our results are perhaps not surprising [59,6,9].…”

Section: Discussioncontrasting

confidence: 58%

“…This can have immediate and long-term effects on the morphological, physiological and behavioral development of littermates, including on postnatal body mass and growth [14,10]. In laboratory mice (Mus musculus), for example, young of both sexes located between two male fetuses (2M offspring) have greater postnatal body mass and long-term growth than fetuses with no male neighbors (0M offspring) [15,16]. It is presently unclear, however, whether this depends on a species' degree of sexual dimorphism.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intrauterine position as a predictor of postnatal growth and survival in the rabbit

Bautista

Rödel

Monclús

et al. 2015

Physiology & Behavior

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Intrauterine position as a predictor of postnatal growth and survival in the rabbit

Bautista

Rödel

Monclús

et al. 2015

Physiology & Behavior

View full text Add to dashboard Cite

“…Male and female oVspring developing adjacent to two siblings of the same sex were heavier than those who shared the incubation environment with two individuals of the opposite sex. EVects of steroid hormone exposure during pregnancy on neonate weight have been repeatedly reported in mammals (Kinsley et al 1986;Petridou et al 1990;Kaijser et al 2000). Among squamate reptiles, manipulative experiments conducted at diVerent postembryonic stages have frequently shown that testosterone inhibits mass gain and skeletal growth (review in , although Uller and Olsson (2003b) reported increased growth of hatchling L. vivipara (live-bearing strain) exposed to exogenous testosterone as embryos.…”

Section: Discussionmentioning

confidence: 96%

Sex of incubation neighbours influences hatchling sexual phenotypes in an oviparous lizard

Braña

2008

Oecologia

View full text Add to dashboard Cite

In many litter-bearing mammals and in a few viviparous reptiles the sex ratio of the entire brood or the sex of the adjacent fetuses induces sex-specific differences in the hatchling's phenotype. This study examines whether the sex of incubation neighbours affects hatchling characteristics in oviparous common lizards (Lacerta vivipara). Oviparous common lizards lay eggs with thin eggshells and, therefore, are an optimal model organism for studying the effects of hormone leakage among developing embryos since the strongest evidence for prenatal sex ratio effects on offspring development comes from viviparous populations of the same species. Groups of three eggs were incubated together and were categorised according to the sex of the resulting hatchlings as either homosex (three hatchlings of the same sex) or heterosex (one male or one female hatchling plus two siblings of the opposite sex). Hatchlings incubated adjacent to siblings of the same sex had larger body mass and body condition. Males tended to have lower ventral scale counts when incubated with other males. Conversely, females tended to have more ventral scales when incubated with other females, indicative of a more feminised phenotype. There was also a significant interaction between hatchling sex and incubation environment with respect to the length of the fourth digit of the hindlimb, likely indicative of masculinisation in heterosex females. This study suggests steroid diffusion between adjacent eggs in a minimally manipulative experiment and provides the first evidence for developmental effects of the exogenous hormonal environment in near natural conditions in an oviparous amniote. Implications of these results for the evolution of within-clutch sex ratio are discussed.

show abstract

“…Fetuses located between two males have increased concentrations of testosterone compared to fetuses located between two females [2], and such fetuses are heavier, suggesting that the intrauterine position may influence metabolic set points involved in the regulation of body weight and fat storage [3]. …”

Section: Introductionmentioning

confidence: 99%

Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

et al. 2017

View full text Add to dashboard Cite

BackgroundThe comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs.MethodsThe data were derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) database, and included 68,494 SS and 53,808 OS dizygotic twin individuals above the age of 20 years from 31 twin cohorts representing 19 countries. Zygosity was determined by questionnaires or DNA genotyping depending on the study. Multiple regression and logistic regression models adjusted for cohort, age, and birth year with the twin type as a predictor were carried out to compare height and BMI in twins from OS pairs with those from SS pairs and to calculate the adjusted odds ratios and 95% confidence intervals for being overweight or obese.ResultsOS females were, on average, 0.31 cm (95% confidence interval (CI) 0.20, 0.41) taller than SS females. OS males were also, on average, taller than SS males, but this difference was only 0.14 cm (95% CI 0.02, 0.27). Mean BMI and the prevalence of overweight or obesity did not differ between males and females from SS and OS twin pairs. The statistically significant differences between OS and SS twins for height were small and appeared to reflect our large sample size rather than meaningful differences of public health relevance.ConclusionsWe found no evidence to support the hypothesis that prenatal hormonal exposure or postnatal socialization (i.e., having grown up with a twin of the opposite sex) has a major impact on height and BMI in adulthood.Electronic supplementary materialThe online version of this article (doi:10.1186/s13293-017-0134-x) contains supplementary material, which is available to authorized users.

show abstract

Prior intrauterine position influences body weight in male and female mice

Cited by 34 publications

References 20 publications

Intrauterine position as a predictor of postnatal growth and survival in the rabbit

Intrauterine position as a predictor of postnatal growth and survival in the rabbit

Sex of incubation neighbours influences hatchling sexual phenotypes in an oviparous lizard

Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Contact Info

Product

Resources

About