Prior Immunization with Severe Acute Respiratory Syndrome (SARS)-Associated Coronavirus (SARS-CoV) Nucleocapsid Protein Causes Severe Pneumonia in Mice Infected with SARS-CoV

Yasui, Fumihiko; Kai, Chieko; Kitabatake, Masahiro; Inoue, Satoshi; Yoneda, Misako; Yokochi, Shoji; Kase, Ryoichi; Sekiguchi, Satoshi; Morita, Kouichi; Hishima, Tsunekazu; Suzuki, Hidenori; Karamatsu, Katsuo; Yasutomi, Yasuhiro; Shida, Hisatoshi; Kidokoro, Minoru; Mizuno, Kyosuke; Matsushima, Kouji; Kohara, Michinori

doi:10.4049/jimmunol.181.9.6337

Cited by 247 publications

(256 citation statements)

References 56 publications

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“…In the present study, we not only confirmed impaired formation of B-cell follicles after H5N1 influenza virus infection, but also showed potentiation of the activation of dendritic cell/T-cell interaction (and improved antibody responses) in H5N1-infected animals previously immunized with rVV-H5N1-HA. Our previous studies and those of others have demonstrated the induction of memory T-cell and B-cell responses following vaccination with recombinant vaccinia virus16171819. Further studies will be needed to clarify the efficacy of T-cell-mediated responses in the alleviation of H5N1 HPAI virus infection-associated symptoms following vaccination with recombinant vaccinia virus.…”

Section: Discussionmentioning

confidence: 83%

“…To reinforce antibody responses of macaques infected with H5N1 HPAI virus, macaques were immunized intradermally with a single dose of rVV-H5 HA, a recombinant vaccinia virus (derived from the highly attenuated strain LC16m8)15 that harbors the gene encoding the H5 hemagglutinin (HA) protein (Clade 2.3.4) under control of an ATI/p7.5 synthetic hybrid promoter16171819. Following subsequent H5N1 HPAI virus infection, macaques primed with rVV-H5 HA displayed formation of mature GCs (with an apparent outer layer of IgD + B-cell follicles) in a manner that resembled that seen following H1N1 pdm virus infection (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus

Yasui

Itoh

Ikejiri

et al. 2016

Sci Rep

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H5N1 highly pathogenic avian influenza (H5N1 HPAI) virus causes elevated mortality compared with seasonal influenza viruses like H1N1 pandemic influenza (H1N1 pdm) virus. We identified a mechanism associated with the severe symptoms seen with H5N1 HPAI virus infection. H5N1 HPAI virus infection induced a decrease of dendritic cell number in the splenic extrafollicular T-cell zone and impaired formation of the outer layers of B-cell follicles, resulting in insufficient levels of antibody production after infection. However, in animals vaccinated with a live recombinant vaccinia virus expressing the H5 hemagglutinin, infection with H5N1 HPAI virus induced parafollicular dendritic cell accumulation and efficient antibody production. These results indicate that a recombinant vaccinia encoding H5 hemagglutinin gene does not impair dendritic cell recruitment and can be a useful vaccine candidate.

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Section: Discussionmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus

Yasui

Itoh

Ikejiri

et al. 2016

Sci Rep

Self Cite

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“…However, some studies showed that purified human neutrophil defensin (HNP1‐3) and rabbit neutrophil defensins (RNP1–5) could neither inhibit nor kill SARS‐CoV 68,69 …”

Section: Innate Immune Responsementioning

confidence: 99%

Coronavirus infections and immune responses

Fan

Lai

et al. 2020

Journal of Medical Virology

1,606

1,770

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Coronaviruses (CoVs) are by far the largest group of known positive-sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved Coronaviruses have posed a global threat to public health. The immune response is essential to control and eliminate CoV infections, however, maladjusted immune responses may result in immunopathology and impaired pulmonary gas exchange. Gaining a deeper understanding of the interaction between Coronaviruses and the innate immune systems of the hosts may shed light on the development and persistence of inflammation in the lungs and hopefully can reduce the risk of lung inflammation caused by CoVs. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment.

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“…However, an early concern for application of a SARS-CoV vaccine was the experience with animal coronavirus vaccines, which induced enhanced disease and immunopathology in animals when challenged with infectious virus [96]. Indeed, a similar immunopathologic reaction has been described in mice vaccinated with a SARS-CoV vaccine and subsequently challenged with SARS-CoV [97,98,99,100,101]. Thus, safety concerns related to effectiveness and safety for vaccinated persons, especially if exposed to other coronaviruses, should be carefully examined.…”

Section: Epidemiology and Impact Of Coronaviruses In Human Healthmentioning

confidence: 99%

Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies

Geller

Varbanov

Duval

2012

Viruses

379

374

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The Coronaviridae family, an enveloped RNA virus family, and, more particularly, human coronaviruses (HCoV), were historically known to be responsible for a large portion of common colds and other upper respiratory tract infections. HCoV are now known to be involved in more serious respiratory diseases, i.e. bronchitis, bronchiolitis or pneumonia, especially in young children and neonates, elderly people and immunosuppressed patients. They have also been involved in nosocomial viral infections. In 2002–2003, the outbreak of severe acute respiratory syndrome (SARS), due to a newly discovered coronavirus, the SARS-associated coronavirus (SARS-CoV); led to a new awareness of the medical importance of the Coronaviridae family. This pathogen, responsible for an emerging disease in humans, with high risk of fatal outcome; underline the pressing need for new approaches to the management of the infection, and primarily to its prevention. Another interesting feature of coronaviruses is their potential environmental resistance, despite the accepted fragility of enveloped viruses. Indeed, several studies have described the ability of HCoVs (i.e. HCoV 229E, HCoV OC43 (also known as betacoronavirus 1), NL63, HKU1 or SARS-CoV) to survive in different environmental conditions (e.g. temperature and humidity), on different supports found in hospital settings such as aluminum, sterile sponges or latex surgical gloves or in biological fluids. Finally, taking into account the persisting lack of specific antiviral treatments (there is, in fact, no specific treatment available to fight coronaviruses infections), the Coronaviridae specificities (i.e. pathogenicity, potential environmental resistance) make them a challenging model for the development of efficient means of prevention, as an adapted antisepsis-disinfection, to prevent the environmental spread of such infective agents. This review will summarize current knowledge on the capacity of human coronaviruses to survive in the environment and the efficacy of well-known antiseptic-disinfectants against them, with particular focus on the development of new methodologies to evaluate the activity of new antiseptic-disinfectants on viruses.

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Prior Immunization with Severe Acute Respiratory Syndrome (SARS)-Associated Coronavirus (SARS-CoV) Nucleocapsid Protein Causes Severe Pneumonia in Mice Infected with SARS-CoV

Cited by 247 publications

References 56 publications

Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus

Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus

Coronavirus infections and immune responses

Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies

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