Prior human polyomavirus and papillomavirus infection and incident lung cancer: a nested case–control study

Abstract

Purpose To test whether infection with select human polyomaviruses (HPyV) and human papillomaviruses (HPV) is associated with incident lung cancer. Methods We performed a nested case-control study, testing serum from the Carotene and Retinol Efficacy Trial (CARET), conducted 1985–2005, for antibodies to Merkel cell (MCV), KI (KIV), and WU (WUV) HPyVs as well as to six high-risk and two low-risk HPV types. Incident lung cancer cases (n=200) were frequency-matched with controls (n=200) on age, enrollment and blood draw dates, intervention arm assignment, and the number of serum freeze / thaw cycles. Sera were tested using multiplex liquid bead microarray antibody assays. We used logistic regression to assess the association between HPyV and HPV antibodies and lung cancer. Results There was no evidence of a positive association between levels of MCV, KIV, or WUV antibodies and incident lung cancer (P-corrected>0.10 for all trend tests; odds ratio (OR) range 0.72 to 1.09, P-corrected>0.10 for all). There was also no evidence for a positive association between HPV 16 or 18 infection and incident lung cancer (P-corrected≥0.10 for all trend tests; OR range 0.25 to 2.54, P>0.05 for all OR>1), but the number of persons with serologic evidence of these infections was small. Conclusions Prior infection with any of several types of HPyV or HPV was not associated with subsequent diagnosis of lung cancer. Infection with these viruses likely does not influence a person’s risk of lung cancer in Western smoking populations.

Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects

“…While studies targeting at the direct relationship between lung cancer and lung microbiome are quite limited at present, there have been interesting studies documenting persistent lung infections and inflammation can favor carcinogenesis . And certain types of microbial agents or products may positively or negatively modulate lung cancer development and/or progression .…”

“…While studies targeting at the direct relationship between lung cancer and lung microbiome are quite limited at present, there have been interesting studies documenting persistent lung infections and inflammation can favor carcinogenesis. [25][26][27][28][29][30][31][32] And certain types of microbial agents or products may positively or negatively modulate lung cancer development and/or progression. 27,30,32,33 A large epidemiological study in humans suggested that the frequency of lung cancer increases upon use of repeated courses of antibiotics providing circumstantial evidence that some links may exist between the bacterial microbiota and lung cancer.…”

Absence of an association of human polyomavirus and papillomavirus infection with lung cancer in China: a nested case–control study

“…In this seroepidemiologic study of the association of HPyV and HPV and incident lung cancer in Asia, multivariable regression analyses of pooled histology types and visual exploration of boxplots stratified by histology type demonstrated no evidence of an association between the levels of these viral antibodies and lung cancer. These results are consistent with our previous seroepidemiologic study in an American population, which also found no association between HPyV antibody levels and lung cancer [ 21 ].…”

“…Despite prior infection with human polyomaviruses being nearly ubiquitous [ 19 ], prior studies report that high levels of MCV antibodies were associated with Merkel cell carcinoma [ 20 ]. However, in the only other seroepidemiologic study, antibodies to MCV, KIV and WUV were not associated with lung cancer in a US population [ 21 ]. Nevertheless, given the influence of host genetics on susceptibility to cancer, these associations may differ in different populations.…”

Survey of KI, WU, MW, and STL Polyomavirus in Cancerous and Non-Cancerous Lung Tissues

“…The association between seropositivity for KIPyV and for WUPyV and lung cancer was studied previously, antibodies against VP1 (viral protein 1) and small tumour antigen were detected and analysed. Colombara et al [31, 32] found that previous infections with these polyomaviruses were not associated with lung cancer. The DNA prevalence of KIPyV and WUPyV was studied in different cancer types [9, 11-13, 33-39], but only KIPyV was detected in lung carcinomas [11] and in benign skin tumours [35].…”