Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O<sub>2</sub> uptake kinetics during subsequent moderate‐intensity exercise in healthy young adults

Gurd, Brendon J.; Peters, Sandra J.; Heigenhauser, George J. F.; LeBlanc, Paul J.; Doherty, Timothy J.; Paterson, Donald H.; Kowalchuk, John M.

doi:10.1113/jphysiol.2006.112706

Cited by 83 publications

(62 citation statements)

References 61 publications

(101 reference statements)

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“…A number of studies have measured τVO 2p values in young untrained men (Berger et al, 2006b;Gurd et al, 2006Gurd et al, , 2008Koppo et al, 2004;McKay et al, 2009;Murias et al, 2010; our group mean τVO 2p values in young (26 s) are in agreement with these studies which reported a range between 21 and 34 s. Additionally, a number of studies have examined τVO 2p values in older untrained men (Berger et al, 2006a;Chilibeck et al, 1996;Gurd et al, 2008;Murias et al, 2010); our group mean τVO 2p values in the old untrained (42 s)…”

Section: Discussionsupporting

confidence: 80%

“…Conflicting evidence exists in the literature in both human and canine models. By increasing the activation of PDH via a pharmacological intervention (dichloroacetate: DCA) or heavy-priming exercise there was a significant decrease of the contribution of substrate-level phosphorylation during MOD (Gurd et al, 2006;Howlett et al, 1999). These findings would suggest that the reduction of substrate-level phosphorylation would stem from a more rapid activation of both oxidative phosphorylation and muscle O 2 utilization.…”

Section: Near-infared Spectroscopymentioning

confidence: 77%

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Effects of Age and Long-Term Endurance Training on V·O2 Kinetics

Grey

Spencer

Belfry

et al. 2015

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Discussionsupporting

confidence: 80%

Section: Near-infared Spectroscopymentioning

confidence: 77%

Effects of Age and Long-Term Endurance Training on V·O2 Kinetics

Grey

Spencer

Belfry

et al. 2015

Medicine &Amp; Science in Sports &Amp; Exercise

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“…However, the effects of prior exercise on PCr breakdown appear to be less consistent in the literature. Studies have demonstrated that [PCr] is higher (Campbell-O'Sullivan et al 2002;Rossiter et al 2001), lower (Sahlin et al 2005), or unchanged (Gurd et al 2006) during the early stages of a subsequent bout of exercise compared to corresponding times during the initial bout of exercise. These apparent contradictions in the literature may be related to the method of measurement (Phosphorus-31 magnetic resonance spectroscopy, 31 P-MRS vs. muscle biopsy), intensity of prior exercise, recovery time between exercise bouts, and the intracellular hydrogen ion concentration ([H + ] i ) at the onset of the subsequent exercise.…”

Section: Introductionmentioning

confidence: 97%

“…Several studies have shown that prior heavy-intensity exercise either accelerates (e.g., Fukuba et al 2004;Gurd et al 2006;Paterson et al 2005;Rossiter et al 2001) or increases the amplitude (e.g., Burnley et al 2002Burnley et al , 2006 of the fundamental, phase II VO 2 kinetic response, reflecting muscle O 2 consumption (Grassi et al 1996). Furthermore, during heavy-intensity exercise performed in a supine or prone position, where muscle perfusion pressure is reduced, studies have consistently suggested that O 2 availability is a limiting factor of muscle O 2 consumption at the onset of exercise (Endo et al 2005;Fukuba et al 2004;Hughson et al 1993;Jones et al 2006;Perrey et al 2001).…”

Section: Introductionmentioning

confidence: 98%

Effects of recovery time on phosphocreatine kinetics during repeated bouts of heavy-intensity exercise

et al. 2008

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The purpose of this study was to examine the kinetics of phosphocreatine (PCr) breakdown in repeated bouts of heavy-intensity exercise separated by three different durations of resting recovery. Healthy young adult male subjects (n = 7) performed three protocols involving two identical bouts of heavy-intensity dynamic plantar flexion exercise separated by 3, 6, and 15 min of rest. Muscle high-energy phosphates and intracellular acid-base status were measured using phosphorus-31 magnetic resonance spectroscopy. In addition, the change in concentration of total haemoglobin (Delta[Hb(tot)]) and deoxy-haemoglobin (Delta[HHb]) were monitored using near-infrared spectroscopy. Prior exercise resulted in an elevated (P < 0.05) intracellular hydrogen ion ([H(+)](i)) after 3 min (182 +/- 72 (SD) nM; pH 6.73) and 6 min (112 +/- 19 nM; pH 6.95) but not after 15 min (93 +/- 8 nM; pH 7.03) compared to pre-exercise in Con (90 +/- 3 nM; pHi 7.05). The on-transient time constant (tau) of the PCr primary component was not different amongst the exercise bouts. However, in each of the subsequent bouts the amplitude of the PCr slow component, total PCr breakdown, and rise in [H(+)](i) were reduced (P < 0.05). At exercise onset, Delta[Hb(tot)] was increased (P < 0.05) and the Delta[HHb] kinetic response was slowed (P < 0.05) in the exercise after 3 min, consistent with improved muscle perfusion. In summary, neither the level of acidosis or muscle perfusion at the onset of exercise appeared to be directly related to the time course of the on-transient PCr primary component or the magnitude of the PCr slow component during subsequent bouts of exercise.

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“…Among these, increased muscle oxygen delivery may play a crucial role for its potentially direct effect (DeLorey et al 2007;Endo et al 2005;Faisal et al 2009), although enhanced activity of muscle oxidative enzymes and alterations of motor unit recruitment patterns have also been considered (for a review of these alternative hypotheses, see Poole and Jones 2012). According to Faisal et al (2009), greater oxygen delivery with increased leg blood flow after prior heavy exercise (Fukuba et al 2007), or an elevation in pyruvate dehydrogenase and intracellular lactate and acetyl CoA concentrations (Gurd et al 2006), may generate an increase in PO 2 following elevated oxygen delivery.…”

Section: The Effect Of Priming Exercisementioning

confidence: 97%

Exercise Transients

Ferretti¹

2015

Energetics of Muscular Exercise

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The steady state of light constant-power submaximal exercise is attained after at least 3 min since the exercise start. Although the application of mechanical power is practically immediate, the rate of oxygen uptake _ V O 2 À Á increases at a remarkably slower rate: a metabolic transient phase occurs, during which _ V O 2 , despite increasing, is insufficient to provide all the metabolic power that is necessary to sustain ATP resynthesis, so that an oxygen deficit is incurred. The oxygen deficit consists of (i) an obligatory component, covered by phosphocreatine breakdown, reflecting the kinetics of glycolysis activation in the contracting muscles, and characterized by an invariant time constant independent of the exercise intensity and (ii) a facultative component, covered by anaerobic lactic metabolism (early lactate accumulation), due to the dissociation between cardiopulmonary response and muscular response at elevated powers, and characterized by a time constant depending on the exercise intensity. The kinetics of _ V O 2 upon exercise onset is described with exponential equations. The implications of single-and doubleexponential models are discussed. The former model carries along the assumption that the kinetics of _ V O 2 determined at the mouth reflects the kinetics of _ V O 2 in the contracting muscles. This correspondence, however, does not hold anymore when early lactate appears. The latter model, in particular, implies a rapid phase (phase I), which has been related to the fast cardiovascular responses at exercise start. A singleexponential model assumes also that the exercising muscles behave as dynamic linear first-order systems that, as such, admit only one transfer function. On this basis, ramp exercise and sinusoidal exercise, typically two unsteady-state conditions, are discussed. More recently, at powers higher than the critical power (see Chap. 5), the so-called slow component, or third phase of the _ V O 2 kinetics, has been also characterized. The energetic meaning of the slow component is also discussed. Finally, some methodological aspects of single-breath analysis of pulmonary gas exchange are discussed.

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Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O₂ uptake kinetics during subsequent moderate‐intensity exercise in healthy young adults

Cited by 83 publications

References 61 publications

Effects of Age and Long-Term Endurance Training on V·O2 Kinetics

Effects of Age and Long-Term Endurance Training on V·O2 Kinetics

Effects of recovery time on phosphocreatine kinetics during repeated bouts of heavy-intensity exercise

Exercise Transients

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Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O2 uptake kinetics during subsequent moderate‐intensity exercise in healthy young adults

Cited by 83 publications

References 61 publications

Effects of Age and Long-Term Endurance Training on V·O2 Kinetics

Effects of Age and Long-Term Endurance Training on V·O2 Kinetics

Effects of recovery time on phosphocreatine kinetics during repeated bouts of heavy-intensity exercise

Exercise Transients

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Product

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Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O₂ uptake kinetics during subsequent moderate‐intensity exercise in healthy young adults