Prior damage to lower motor neuron triggering myasthenia gravis

Steiner, Israel; Goldstein, Lilach; Hellmann, Mark A.; Lotan, Itay

doi:10.1002/mus.25026

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…A total of 23 full-text articles were assessed for eligibility. Four studies had an obscure diagnosis of either ALS or MG or lack of important information (5–8), five differentiated the two diseases but not their coexistence (9–13), two reported coexistence of MG and lower motor neuron syndrome (14, 15), and one described an ALS patient who developed myasthenia possibly due to the use of riluzole (16). Finally, 11 articles that reported cases diagnosed as coexistence of ALS and MG were identified (4, 17–26).…”

Section: Resultsmentioning

confidence: 99%

Amyotrophic Lateral Sclerosis and Myasthenia Gravis Overlap Syndrome: A Review of Two Cases and the Associated Literature

et al. 2017

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ObjectiveTo describe the characteristics of patients with amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG) overlap syndrome and explore the relationship between the two diseases.MethodsWe conducted a search of medical records at Peking Union Medical University Hospital from 1983 to 2015 for coexistence of ALS and MG and searched the PubMed database for all literature describing ALS and MG overlap syndrome published through December 2016. We analyzed the clinical and neurophysiological characteristics of patients by groups according to strict diagnostic criteria.ResultsWe presented 2 patients in our database with combined ALS and MG, and together with 25 cases reported in the literature, the patients were divided into 4 groups: 12 patients with MG followed by ALS, 8 patients with ALS followed by MG, 5 ALS patients with false-positive anti-acetylcholine receptor, and the other 2 ALS patients with only myasthenia symptoms. Most patients had limb onset ALS, and myasthenia symptoms mainly affected ocular and bulbar muscles. Clinical and neurophysiological characteristics were summarized.ConclusionThese findings support the conclusion that immunological mechanisms and alterations in the neuromuscular junction are related to ALS pathogenesis.

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