Prions in the Environment

Bartelt–Hunt, Shannon L.; Bartz, Jason C.; Yuan, Qi

doi:10.1007/978-3-031-20565-1_10

Cited by 1 publication

(1 citation statement)

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“…Additionally, dietary intake may influence transmission of prion diseases through consumption of infected animal products (meat, milk, etc .) or through infectious prions on or within plants and other biotic and abiotic material in the environment ( Bartelt-Hunt, Bartz & Yuan, 2023 ; Gough & Maddison, 2010 ; Inzalaco et al, 2023 ; Johnson et al, 2011 ; Konold et al, 2008 ; Kuznetsova et al, 2023 ; Lacroux et al, 2008 ; Prusiner, 1997 ).…”

Section: Introductionmentioning

confidence: 99%

Genetic characterization of the prion protein gene in camels (Camelus) with comments on the evolutionary history of prion disease in Cetartiodactyla

Wright,

Reddock,

Roberts

et al. 2024

PeerJ

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Transmissible spongiform encephalopathies (TSEs) are a fatal neurogenerative disease that include Creutzfeldt–Jakob disease in humans, scrapie in sheep and goats, bovine spongiform encephalopathy (BSE), and several others as well as the recently described camel prion disease (CPD). CPD originally was documented in 3.1% of camels examined during an antemortem slaughterhouse inspection in the Ouargla region of Algeria. Of three individuals confirmed for CPD, two were sequenced for the exon 3 of the prion protein gene (PRNP) and were identical to sequences previously reported for Camelus dromedarius. Given that other TSEs, such as BSE, are known to be capable of cross–species transmission and that there is household consumption of meat and milk from Camelus, regulations to ensure camel and human health should be a One Health priority in exporting countries. Although the interspecies transmissibility of CPD currently is unknown, genotypic characterization of Camelus PRNP may be used for predictability of predisposition and potential susceptibility to CPD. Herein, eight breeds of dromedary camels from a previous genetic (mitochondrial DNA and microsatellites) and morphological study were genotyped for PRNP and compared to genotypes from CPD–positive Algerian camels. Sequence data from PRNP indicated that Ethiopian camels possessed 100% sequence identity to CPD–positive camels from Algeria. In addition, the camel PRNP genotype is unique compared to other members of the Orders Cetartiodactyla and Perissodactyla and provides an in–depth phylogenetic analysis of families within Cetartiodactyla and Perissodactyla that was used to infer the evolutionary history of the PRNP gene.

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