Prion receptors, prion internalization, intra- and inter-cellular transport

Different tau fibril types reduce prion level in chronically and de novo infected cells

“…This could result in the hampering of PrP C recycling through the endocytic compartments preventing its interaction with PrP Sc and the progress of the infectious cycle. During the established infection, tau fibril binding to PrP C may stabilize the protein at the plasma membrane, preventing its interaction with PrP Sc in the endocytic compartments, where the conversion most likely occurs ( 36 , 39 , 40 ).…”