“…Ideally a multidisciplinary team, including a neurologist, a genetic counselor, and a social worker will have the opportunity to manage genetic prion disease cases together. Key preparation will include understanding the penetrance 33 should be employed. Bearing in mind this limitation of NGS, in the event that prion disease is part of a broad differential diagnosis of a neurodegenerative disease and there is a family history of a similar condition, a large NGS dementia panel may be considered as a first step to rule out conditions such as familial Alzheimer's disease or frontotemporal dementia.…”