Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure

Planchette, Carole; Pichler, Heinz; Wimmer-Teubenbacher, Miriam; Gruber, Michael; Gruber‐Wölfler, Heidrun; Mohr, Stefan; Tetyczka, Carolin; Hsiao, Wen‐Kai; Paudel, Amrit; Roblegg, Eva; Khinast, Johannes G.

doi:10.1016/j.ijpharm.2015.10.054

Cited by 53 publications

(35 citation statements)

References 15 publications

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“…An exciting advancement in developing understanding of actives printed onto ODFs to produce personalised dosage forms has been described in a recent publication (Planchette et al, 2015). A non-contact printing system that incorporates complementary inkjet technologies (piezoelectric actuator or solenoid valve) was utilised (Figure 2).…”

Section: Inkjet Printing On Odfs: a Case Studymentioning

confidence: 99%

Orodispersible films: Towards drug delivery in special populations

Scarpa

Stegemann

Hsiao

et al. 2017

International Journal of Pharmaceutics

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Section: Inkjet Printing On Odfs: a Case Studymentioning

confidence: 99%

Orodispersible films: Towards drug delivery in special populations

Scarpa

Stegemann

Hsiao

et al. 2017

International Journal of Pharmaceutics

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“…Smooth substrates facilitated the formation of circular dots, or dumbbell-shaped when coalesced, with regular edges, while rougher substrates promoted the formation of irregular shaped dots due to the pinning of the contact line. The porosity of yMCC (Planchette et al, 2016) caused the dots of dried ink to vanish from the substrate surface over a course of eight weeks at ambient conditions. Genina et al (2013) argues that porous substrates are better penetrated by the API containing inks and therefore cause entrapment of the API.…”

Section: Discussionmentioning

confidence: 99%

“…List, the gelatin and HPMC films are smoother than the Tesa and MCC films appeared to have rougher surfaces. yMCC was found to be porous (Planchette et al, 2016) which was even more apparent once SP was printed onto the substrate (Figure 1). The roughness of the surface had an influence on the shape of the ink drops.…”

Section: Morphological Investigation Using Semmentioning

confidence: 96%

“…Hz and a pulse of 50 ms forming drops with an average drop volume of 430 pl for a standard deviation of 1.5% (Planchette et al, 2016) 2.4 Scanning electron microscopy SEM images were taken with a JEOL JSM 5600 (JEOL Ltd., Tokyo, Japan) with an adjusted acceleration of 7 kV. Before analysis the samples were prepared by aluminum sputtering in vacuum.…”

Section: Printingmentioning

confidence: 99%

“…Printing enables a versatile adjustment of the dose by varying the amount of the printed ink which contains the API. Furthermore, it offers the possibility to print a combination of inks and therefore APIs onto a single dosage form to enable personalized drug delivery (Alomari et al, 2015;Planchette et al, 2016). Additionally, the printing process is largely independent from the substrates used when contactless technologies such as ink jet printing systems are used (Daly et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pharmaceutical-grade oral films as substrates for printed medicine

Wimmer-Teubenbacher

Planchette

Pichler

et al. 2018

International Journal of Pharmaceutics

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In contact-less printing, such as piezo-electric drop on demand printing used in the study, the drop formation process is independent of the substrate. This means that having developed a printable formulation, printed pharmaceutical dosage forms can be obtained on any pharmaceutical grade substrate, such as polymer-based films. In this work we evaluated eight different oral films based on their suitability as printing substrates for sodium picosulfate. The different polymer films were compared regarding printed spot morphology, chemical stability and dissolution profile. The morphology of printed sodium picosulfate was investigated with scanning electron microscopy and optical coherence tomography. The spreading of the deposited drops was found to be governed by the contact angle of the ink with the substrate. The form of the sodium picosulfate drops changed on microcrystalline cellulose films at ambient conditions over 8 weeks and stayed unchanged on other tested substrates. Sodium picosulfate remained amorphous on all substrates according to small and wide angle X-ray scattering, differential scanning calorimetry and polarized light microscopy measurements. The absence of chemical interactions between the drug and substrates, as indicated by infrared spectroscopy, makes all tested substrates suitable for printing sodium picosulfate onto them.

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Inkjet Printing of Pharmaceuticals

Carou‐Senra,

Rodríguez‐Pombo,

Awad

et al. 2023

Advanced Materials

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Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer‐by‐layer, to create three‐dimensional (3D) objects or two‐dimensional (2D) patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever‐evolving demands of personalized medicine in the healthcare industry. Although originally developed for non‐healthcare applications, IJP harnesses the potential of pharma‐inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma‐inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D‐printed materials, showcasing their diverse advantages, whilst exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in the era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient‐specific treatment is on the horizon of becoming a tangible reality.This article is protected by copyright. All rights reserved

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Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure

Cited by 53 publications

References 15 publications

Orodispersible films: Towards drug delivery in special populations

Orodispersible films: Towards drug delivery in special populations

Pharmaceutical-grade oral films as substrates for printed medicine

Inkjet Printing of Pharmaceuticals

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